Ergogenic Benefits of β‐Hydroxy‐β‐Methyl Butyrate (HMB) Supplementation on Body Composition and Muscle Strength: An Umbrella Review of Meta‐Analyses
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13671
Abstract: β‐Hydroxy‐β‐methyl butyrate (HMB) is a metabolite of the amino acid leucine, known for its ergogenic effects on body composition and strength. Despite these benefits, the magnitude of these effects remains unclear due to variability among… read more here.
Keywords: body composition; muscle; hydroxy methyl; body ... See more keywords
Synthesis and aminomethylation of regioisomeric 6-hydroxy-4-methyl- and 4-hydroxy-6-methylaurones
Sign Up to like & getrecommendations! Published in 2018 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-018-2360-5
Abstract: The regioisomeric 6-hydroxy-4-methyl- and 4-hydroxy-6-methylaurones were synthesized. Aminomethylation by the action of aminals of secondary amines was investigated. It was shown that the reaction proceeds selectively with the formation of 7-aminomethyl-6-hydroxy-4-methyl- and 5-aminomethyl-4-hydroxy-6-methylaurones, respectively. The… read more here.
Keywords: hydroxy methylaurones; methyl hydroxy; regioisomeric hydroxy; hydroxy methyl ... See more keywords
Investigation of the multicomponent reaction of 5-hydroxy-2-methyl-4H-pyran-4-one with carbonyl compounds and Meldrum's acid
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DOI: 10.1007/s10593-019-02542-1
Abstract: Herein, we report the studies of the multicomponent reaction of 5-hydroxy-2-methyl-4H-pyran-4-one with carbonyl compounds and Meldrum's acid. General methods for the synthesis of 6-methyl-3,4-dihydropyrano[3,2-b]pyran-2,8-diones, 3-(3-hydroxy-6-methyl-4-oxo-4H-pyran-2-yl)propanoic acid amides and esters, as well as 7-oxo-7H-furo[3,2-b]pyran-3-ylacetic acids were… read more here.
Keywords: methyl; multicomponent reaction; hydroxy methyl; reaction hydroxy ... See more keywords
Competent, selective and high yield of 7-hydroxy-4-methyl coumarin over sulfonated mesoporous silica as solid acid catalysts
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DOI: 10.1007/s10934-017-0414-1
Abstract: Highly ordered mesoporous MCM-41 and SBA-15 have been synthesized and functionalized with different amounts of propyl sulfonic acid groups using 3-mercaptopropyltrimethoxysilane as sulfur source. The synthesized catalysts have been well-characterized by different techniques such as… read more here.
Keywords: acid; methyl coumarin; yield hydroxy; hydroxy methyl ... See more keywords
Condensation of 5-hydroxy-2-methyl-4H-pyran-4-one with arylglyoxals. Synthesis and properties of 2-aryl-1-(3-hydroxy-6-methyl-4-oxo-4H-pyran-2-yl)ethane-1,2-diones
Sign Up to like & getrecommendations! Published in 2018 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-018-2301-6
Abstract: A convenient method was developed for the synthesis of previously unknown 1,2-diketones, based on the condensation of 5-hydroxy-2-methyl-4H-pyran-4-one with arylglyoxals. The study demonstrated the possibility of using these compounds to synthesize nitrogen-containing hetero cyclic systems… read more here.
Keywords: methyl; hydroxy methyl; condensation hydroxy; methyl pyran ... See more keywords
Feeding β-hydroxy β-methyl butyrate to sows in late gestation improves litter and piglet performance to weaning and colostrum immunoglobulin concentrations
Sign Up to like & getrecommendations! Published in 2021 at "Animal Feed Science and Technology"
DOI: 10.1016/j.anifeedsci.2021.114889
Abstract: Abstract Positive effects of β-hydroxy β-methyl butyrate (HMB) on reproductive performance, growth rate and health have been reported in both human and animal studies. However, research into its effect on sow and litter performance is… read more here.
Keywords: piglet; performance; hmb; hydroxy methyl ... See more keywords
Experimental and theoretical investigations of the kinetics and mechanism of the Cl + 4-hydroxy-4-methyl-2-pentanone reaction
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DOI: 10.1016/j.atmosenv.2017.07.038
Abstract: Abstract The reaction of 4-hydroxy-4-methyl-2-pentanone (4H4M2P) with Cl atoms was studied for the first time experimentally and theoretically. Relative kinetic measurements were carried out at room temperature and 1 bar of synthetic air/N 2 in two… read more here.
Keywords: methyl pentanone; rate; reaction; hydroxy methyl ... See more keywords
Synthesis, characterization and molecular modeling of binuclear Pd(II) and Ir(IV) complexes with bis [4-hydroxy-6-methyl-3-{(1E)-N-[2-(ethylamino)ethyl]ethanimidoyl}-2H-pyran-2-one]: Application to detection of glucose
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2018.05.075
Abstract: Abstract Two binuclear Pd (II) and Ir(IV) complexes with new bis [4-hydroxy-6-methyl-3-{(1E)-N-[2-(ethylamino) ethyl] ethanimidoyl}-2H-pyran-2-one] ligand (Schiff base: L) have been prepared and characterized by elemental analysis, ESI-MS, conductivity, NMR (1H NMR, 13C NMR, COSY-NMR, HMBC-NMR… read more here.
Keywords: ethylamino ethyl; hydroxy methyl; geometry; methyl ethylamino ... See more keywords
Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)A Receptor.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00846
Abstract: Certain classes of neuroactive steroids (NASs) are positive allosteric modulators (PAM) of synaptic and extrasynaptic GABAA receptors. Herein, we report new SAR insights in a series of 5β-nor-19-pregnan-20-one analogues bearing substituted pyrazoles and triazoles at… read more here.
Keywords: neuroactive steroids; pregnan one; hydroxy methyl; methyl cyano ... See more keywords
Inhibition of Chikungunya Virus Infection by 4-Hydroxy-1-Methyl-3-(3-morpholinopropanoyl)quinoline-2(1H)-one (QVIR) Targeting nsP2 and E2 Proteins
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.1c00447
Abstract: The re-emergence of Chikungunya virus (CHIKV) infection in humans with no approved antiviral therapies or vaccines is one of the major problems with global significance. In the present investigation, we screened 80 in-house quinoline derivatives… read more here.
Keywords: hydroxy methyl; chikv; inhibition; infection ... See more keywords
First Stereoselective Total Synthesis of Marliolide-(4R,5R,3E)-4-hydroxy-5-methyl-3-tetradecylidenedihydrofuran-2(3H)-one and Vittarilide-B: A Unified Strategy Utilizing a Chiral Pool Approach
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.4c10876
Abstract: The first stereoselective total synthesis of the natural products Marliolide-(4R,5R,3E)-4-hydroxy-5-methyl-3-tetradecylidenedihydrofuran-2(3H)-one (1) and Vittarilide-B (1b) has been accomplished using a carbohydrate-based approach starting from d-glucose. The synthesis of Marliolide-(4R,5R,3E)-4-hydroxy-5-methyl-3-tetradecylidenedihydrofuran-2(3H)-one (1) was achieved in 13 steps with… read more here.
Keywords: tetradecylidenedihydrofuran one; marliolide hydroxy; hydroxy methyl; methyl tetradecylidenedihydrofuran ... See more keywords