Characterization of 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (IspG) from Plasmodium vivax and it's potential as an antimalarial drug target.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2016.12.033
Abstract: The prokaryotic type Methyl Erythritol phosphate (MEP) pathway functional in the apicoplast of Plasmodium is indispensable for the erythrocytic stages of the parasite. It is the sole process of isoprenoids biosynthesis in the parasite and… read more here.
Keywords: methylbut diphosphate; hydroxy methylbut; target; diphosphate ... See more keywords
Crystal structure of 2-chloro-5-(3-hydroxy-3-methylbut-1-yn-1-yl)pyrimidine
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DOI: 10.1107/s2056989017010027
Abstract: The ethynylpyrimidine moiety displays an almost planar geometry. In the crystal, molecules are linked by O—H⋯N and C—Hpyrimidine⋯O hydrogen bonds, forming a three-dimensional supramolecular architecture. read more here.
Keywords: crystal structure; chloro hydroxy; methylbut pyrimidine; hydroxy methylbut ... See more keywords
Microbial (E)-4-hydroxy-3-methylbut-2-enyl pyrophosphate reductase (IspH) and its biotechnological potential: A mini review
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1057938
Abstract: (E)-4-hydroxy-3-methylbut-2-enyl pyrophosphate (HMBPP) reductase (IspH) is a [4Fe-4S] cluster-containing enzyme, involved in isoprenoid biosynthesis as the final enzyme of the methylerythritol phosphate (MEP) pathway found in many bacteria and malaria parasites. In recent years, many… read more here.
Keywords: reductase isph; methylbut enyl; hydroxy methylbut; mini review ... See more keywords