8‐Hydroxy‐1,6‐naphthyridine‐7‐carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease
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DOI: 10.1002/cmdc.202200334
Abstract: Human cytomegalovirus (HCMV) replication requires a metal‐dependent endonuclease at the C‐terminus of pUL89 (pUL89‐C) for viral genome packaging and cleavage. We have previously shown that pUL89‐C can be pharmacologically inhibited with designed metal‐chelating compounds. We… read more here.
Keywords: pul89; human cytomegalovirus; hydroxy naphthyridine; endonuclease ... See more keywords