l-Arginine prevents 4-hydroxy-2-nonenal accumulation and depresses inflammation via inhibiting NF-κB activation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23087
Abstract: 4-Hydroxy-2-nonenal (HNE) is an inducer of inflammation. The aim of this study was to elicit the link between the inhibition of HNE accumulation and the depression of inflammation whether dependent onl-arginine availability in growing rats.… read more here.
Keywords: activation; hydroxy nonenal; hne; arginine ... See more keywords
Effect of 4-hydroxy-2-nonenal on myoglobin-mediated lipid oxidation when varying histidine content and hemin affinity.
Sign Up to like & getrecommendations! Published in 2017 at "Food chemistry"
DOI: 10.1016/j.foodchem.2017.01.035
Abstract: The compound 4-hydroxy-2-nonenal (HNE) dissolved in water was examined to remove potential effects of using ethanol to solubilize the aldehyde such as altering protein structure or redox properties of myoglobin (Mb). HNE became covalently bound… read more here.
Keywords: oxidation; mediated lipid; hemin affinity; hydroxy nonenal ... See more keywords
4-Hydroxy-2-nonenal in food products: A review of the toxicity, occurrence, mitigation strategies and analysis methods
Sign Up to like & getrecommendations! Published in 2020 at "Trends in Food Science and Technology"
DOI: 10.1016/j.tifs.2019.12.011
Abstract: Abstract Background Lipid peroxidation yields a large number of aldehydes and carbonyl-containing compounds, of which the reactive and toxic compound 4-hydroxy-2-nonenal (4-HNE) derived from ω-6 polyunsaturated fatty acids (ω-6 PUFAs) is the most extensively studied.… read more here.
Keywords: mitigation strategies; hydroxy nonenal; toxicity; hne ... See more keywords
Selective Identification and Site-Specific Quantification of 4-Hydroxy-2-nonenal-Modified Proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b05970
Abstract: 4-Hydroxy-2-nonenal (HNE)-modified proteins are closely associated with cellular functions and diseases, so qualitative and quantitative analysis of HNE-modified proteins is very necessary in order to further understand their structures and molecular functions. In this study,… read more here.
Keywords: hne modified; site specific; hydroxy nonenal; modified proteins ... See more keywords
4-Hydroxy-2-nonenal Alkylated and Peroxynitrite Nitrated Proteins Localize to the Fused Mitochondria in Malpighian Epithelial Cells of Type IV Collagen Drosophila Mutants
Sign Up to like & getrecommendations! Published in 2018 at "BioMed Research International"
DOI: 10.1155/2018/3502401
Abstract: Background. Human type IV collagenopathy is associated with mutations within the COL4A1 and to a less extent the COL4A2 genes. The proteins encoded by these genes form heterotrimers and are the highest molar ratio components… read more here.
Keywords: collagen; epithelial cells; fused mitochondria; hydroxy nonenal ... See more keywords
Oxidative Stress Product, 4-Hydroxy-2-Nonenal, Induces the Release of Tissue Factor-Positive Microvesicles From Perivascular Cells Into Circulation
Sign Up to like & getrecommendations! Published in 2020 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.120.315187
Abstract: Supplemental Digital Content is available in the text. Objective: TF (Tissue factor) plays a key role in hemostasis, but an aberrant expression of TF leads to thrombosis. The objective of the present study is to… read more here.
Keywords: hydroxy nonenal; hne; circulation; perivascular cells ... See more keywords
Exposure to the Dioxin-like Pollutant PCB 126 Afflicts Coronary Endothelial Cells via Increasing 4-Hydroxy-2 Nonenal: A Role for Aldehyde Dehydrogenase 2
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DOI: 10.3390/toxics10060328
Abstract: Exposure to environmental pollutants, including dioxin-like polychlorinated biphenyls (PCBs), play an important role in vascular inflammation and cardiometabolic diseases (CMDs) by inducing oxidative stress. Earlier, we demonstrated that oxidative stress-mediated lipid peroxidation derived 4-hydroxy-2-nonenal (4HNE)… read more here.
Keywords: coronary endothelial; hydroxy nonenal; pcb 126; endothelial cells ... See more keywords
L-Methionine inhibits 4-hydroxy-2-nonenal accumulation and suppresses inflammation in growing rats
Sign Up to like & getrecommendations! Published in 2022 at "Nutrition Research and Practice"
DOI: 10.4162/nrp.2022.16.6.729
Abstract: BACKGROUND/OBJECTIVES 4-Hydroxy-2-nonenal (HNE) is a biomarker for oxidative stress to induce inflammation. Methionine is an essential sulfur-containing amino acid with antioxidative activity. On the other hand, the evidence on whether and how methionine can depress… read more here.
Keywords: hydroxy nonenal; hne; methionine; accumulation ... See more keywords
A Computational Insight into Reaction Between Different Amino Acids with Reactive Aldehydes 4-hydroxy-2-nonenal and 4-oxo-2-nonenal
Sign Up to like & getrecommendations! Published in 2019 at "Croatica chemica acta"
DOI: 10.5562/cca3579
Abstract: In this work, we studied in detail the reaction mechanism of modification of arginine (Arg), cysteine (Cys) and histidine (His) model amino acids upon the reaction with biologically relevant reactive aldehydes 4-hydroxy-2-nonenal (HNE) and 4-oxo-2-nonenal… read more here.
Keywords: amino; amino acids; hydroxy nonenal; reaction ... See more keywords