Structural basis for the stereospecific inhibition of the dual proline/hydroxyproline catabolic enzyme ALDH4A1 by trans‐4‐hydroxy‐L‐proline
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4131
Abstract: Aldehyde dehydrogenase 4A1 (ALDH4A1) catalyzes the final steps of both proline and hydroxyproline catabolism. It is a dual substrate enzyme that catalyzes the NAD+‐dependent oxidations of L‐glutamate‐γ‐semialdehyde to L‐glutamate (proline metabolism), and 4‐hydroxy‐L‐glutamate‐γ‐semialdehyde to 4‐erythro‐hydroxy‐L‐glutamate… read more here.
Keywords: inhibition; hydroxyproline; enzyme; proline ... See more keywords
Hydrolysing the soluble protein secreted by Escherichia coli in trans-4-hydroxy-L-proline fermentation increased dissolve oxygen to promote high-level trans-4-hydroxy-L-proline production
Sign Up to like & getrecommendations! Published in 2019 at "Bioengineered"
DOI: 10.1080/21655979.2019.1600966
Abstract: ABSTRACT Trans-4-hydroxy-L-proline (Hyp) production by Escherichia coli (E. coli) in fermentation is a high-oxygen-demand process. E. coli secretes large amounts of soluble protein, especially in the anaphase of fermentation, which is an important factor leading… read more here.
Keywords: soluble protein; production; fermentation; hyp ... See more keywords
Efficacy of Hydroxy-L-proline (HYP) analogs in the treatment of primary hyperoxaluria in Drosophila Melanogaster
Sign Up to like & getrecommendations! Published in 2018 at "BMC Nephrology"
DOI: 10.1186/s12882-018-0980-8
Abstract: BackgroundSubstrate reduction therapy with analogs reduces the accumulation of substrates by inhibiting the metabolic pathways involved in their biosynthesis, providing new treatment options for patients with primary hyperoxalurias (PHs) that often progress to end-stage renal… read more here.
Keywords: hyp analogs; melanogaster; proline hyp; hydroxy proline ... See more keywords
N-Methyl-(2S, 4R)-trans-4-hydroxy-L-proline, the major bioactive compound from Sideroxylon obtusifolium, attenuates pilocarpine-induced injury in cultured astrocytes
Sign Up to like & getrecommendations! Published in 2022 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x2022e12381
Abstract: Glial cells have been implicated in temporal lobe epilepsy in humans and in its models. Astrocytes are lost in several brain regions after acute seizures induced by pilocarpine and may suffer hyperplasia at subsequent time… read more here.
Keywords: methyl trans; induced injury; trans hydroxy; pilocarpine induced ... See more keywords
Structure of Thermococcus litoralis trans-3-hydroxy-l-proline dehydratase in the free and substrate-complexed form.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and Biophysical Research Communications"
DOI: 10.2210/pdb6r77/pdb
Abstract: Abstract Hydroxyprolines (Hyp) are non-standard amino acids derived from the post-translational modification of proteins by prolyl hydroxylase enzymes. Some plants and bacteria produce Hyp, and the isomers trans-3-Hydroxy- l -proline (T3LHyp) and trans-4-Hydroxy- l -proline… read more here.
Keywords: hydroxy proline; trans hydroxy; structure; free substrate ... See more keywords