Physiologically based pharmacokinetic modeling characterizes the drug-drug interaction between saxagliptin and rifampicin in patients with renal impairment.
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DOI: 10.1002/jcph.2223
Abstract: The aim of the present study is to develop physiologically based pharmacokinetic (PBPK) models for saxagliptin and its active metabolite, 5-hydroxy saxagliptin, and to predict the effect of co-administration of rifampicin, a strong inducer of… read more here.
Keywords: hydroxy saxagliptin; renal impairment; rifampicin; drug ... See more keywords