One-step Synthesis of 2-Hydroxy-2-(trifluoromethyl)malonates by Trifluoromethylation of 2-Oxomalonates with Ruppert-Prakash Reagent
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DOI: 10.1246/cl.190942
Abstract: The one-step synthesis of 2-hydroxy-2-(trifluoromethyl)malonates is described. The nucleophilic trifluoromethylation of commercially available 2-oxo-malonates was possible by use of the Ruppert-Pra... read more here.
Keywords: trifluoromethyl malonates; step synthesis; synthesis hydroxy; one step ... See more keywords
3-(((1S,3S)-3-((R)-Hydroxy(4-(trifluoromethyl)phenyl)methyl)-4-oxocyclohexyl)methyl)pentane-2,4-dione: Design and Synthesis of New Stereopure Multi-Target Antidiabetic Agent
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DOI: 10.3390/molecules27103265
Abstract: The chiral drug candidates have more effective binding affinities for their specific protein or receptor site for the onset of pharmacological action. Achieving all carbon stereopure compounds is not trivial in chemical synthesis. However, with… read more here.
Keywords: hydroxy trifluoromethyl; antidiabetic agent; synthesis; stereopure ... See more keywords