Chloramphenicol base chemistry. Part 101: Asymmetric synthesis of α-hydroxy chiral alcohols via intramolecular Michael additions of γ-hydroxy-α, β-unsaturated enones with chloramphenicol base derived bifunctional urea organocatalysts
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DOI: 10.1016/j.tet.2017.03.076
Abstract: We have developed the chloramphenicol base urea-catalyzed intramolecular Michael addition of γ-hydroxy-α, β-unsaturated enones. The oxidation of the resulting products provided facile access to the corresponding α-hydroxy chiral alcohols with good efficiency and enantioselectivity, with… read more here.
Keywords: chloramphenicol base; chemistry; hydroxy unsaturated; unsaturated enones ... See more keywords
Study of the Cross-Metathesis Reaction of α-Hydroxy β,γ-Unsaturated Amides towards a Rapid and Flexible Total Synthesis of Symbioramide and its Isomer
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DOI: 10.1055/s-0036-1588579
Abstract: The reactivity of novel α-hydroxy β,γ-unsaturated amides in cross-metathesis reactions was extensively studied and used to perform a short total synthesis of symbioramide and its isomer from l -serine methyl ester. read more here.
Keywords: symbioramide isomer; unsaturated amides; hydroxy unsaturated; total synthesis ... See more keywords