Organometallic Nucleoside Analogues: Effect of Hydroxyalkyl Linker Length on Cancer Cell Line Toxicity
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DOI: 10.1002/ejic.201600853
Abstract: A new series of chiral ferrocene derivatives containing both a hydroxyalkyl group and a thyminyl group on one cyclopentadienyl ring have been synthesised to probe structure–activity relationships in cancer cell line cytotoxicities. The stereoisomers of… read more here.
Keywords: hydroxyalkyl; cell line; cancer cell;
Precursor‐Directed Synthesis of Apoptosis‐Initiating N‐Hydroxyalkyl Phenylbenzoisoquinolindione Alkaloids
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DOI: 10.1002/open.202200157
Abstract: Abstract A precursor‐directed approach to access N‐hydroxyalkyl phenylbenzoisoquinolindiones (PBIQs) has been developed. Incubation of plant material of Xiphidium caeruleum with hydroxylamines of various chain lengths (C2, C4, C6, C8, C10 and C12) resulted in 11… read more here.
Keywords: synthesis apoptosis; hydroxyalkyl; apoptosis initiating; directed synthesis ... See more keywords
Mechanism of the unusual substituent exchange in the reactions of alkylene oxides with organic compounds bearing β-hydroxyalkyl groups at heteroatoms S, Se, N, and P
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DOI: 10.1007/s11172-017-1899-0
Abstract: The review summarizes the data on the study of the unusual exchange reaction between alkylene oxides and organic compounds of groups 15 and 16 of the Periodic Table bearing β-hydroxyalkyl substituents at the S, Se,… read more here.
Keywords: organic compounds; reaction; exchange; oxides organic ... See more keywords