Substrate Recognition Mechanism of a Trichostatin A-Forming Hydroxyamidotransferase.
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DOI: 10.1021/acs.biochem.3c00025
Abstract: The hydroxyamidotransferase TsnB9 catalyzes hydroxylamine transfer from l-glutamic acid γ-monohydroxamate to the carboxyl group of trichostatic acid to produce the terminal hydroxamic acid group of trichostatin A, which is a potent inhibitor of histone deacetylase… read more here.
Keywords: acid; synthetase; recognition mechanism; hydroxyamidotransferase ... See more keywords