Stereoselective Syntheses of 3′-Hydroxyamino- and 3′-Methoxyamino-2′,3′-Dideoxynucleosides
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DOI: 10.1021/acs.orglett.9b03474
Abstract: Aminonucleosides are used as key motifs in medicinal and bioconjugate chemistry; however, existing strategies toward 3′-hypernucleophilic amine systems do not readily deliver deoxyribo-configured products. We report diastereoselective syntheses of deoxyribo- and deoxyxylo-configured 3′-hydroxyamino- and 3′-methoxyamino-nucelosides… read more here.
Keywords: methoxyamino dideoxynucleosides; hydroxyamino methoxyamino; chemistry; stereoselective syntheses ... See more keywords