Natural diversity of FAD-dependent 4-hydroxybenzoate hydroxylases.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108820
Abstract: 4-Hydroxybenzoate 3-hydroxylase (PHBH) is the most extensively studied group A flavoprotein monooxygenase (FPMO). PHBH is almost exclusively found in prokaryotes, where its induction, usually as a consequence of lignin degradation, results in the regioselective formation… read more here.
Keywords: hydroxybenzoate; hydroxylase; hydroxybenzoate hydroxylase; fad dependent ... See more keywords
Molecular modelling and structure-activity relationship of a natural derivative of o-hydroxybenzoate as a potent inhibitor of dual NSP3 and NSP12 of SARS-CoV-2: in silico study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2026818
Abstract: Abstract The nsp3 macrodomain and nsp12 (RdRp) enzymes are strongly implicated in the virulent regulation of the host immune response and viral replication of SARS-CoV-2, making them plausible therapeutic targets for mitigating infectivity. Remdesivir remains… read more here.
Keywords: structure; hydroxybenzoate; inhibitor; natural derivative ... See more keywords
Metabolic engineering of p‐hydroxybenzoate in poplar lignin
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DOI: 10.1111/pbi.13935
Abstract: Summary Ester‐linked p‐hydroxybenzoate occurs naturally in poplar lignin as pendent groups that can be released by mild alkaline hydrolysis. These ‘clip‐off’ phenolics can be separated from biomass and upgraded into diverse high‐value bioproducts. We introduced… read more here.
Keywords: lignin; metabolic engineering; hydroxybenzoate; poplar lignin ... See more keywords
Modification of N-Terminal Amino Acids of Fungal Benzoate Hydroxylase (CYP53A15) for the Production of p-Hydroxybenzoate and Optimization of Bioproduction Conditions in Escherichia coli.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of microbiology and biotechnology"
DOI: 10.4014/jmb.1711.11030
Abstract: The aromatic compound p-hydroxybenzoate (PHBA) is an important material with multiple applications, including as a building block of liquid crystal polymers in chemical industries. The cytochrome P450 (CYP) enzymes are beneficial monooxygenases for the synthesis… read more here.
Keywords: hydroxybenzoate; escherichia coli; benzoate; cyp53a15 ... See more keywords