Metabolism of hyperpolarized 13C‐acetoacetate to β‐hydroxybutyrate detects real‐time mitochondrial redox state and dysfunction in heart tissue
Sign Up to like & getrecommendations! Published in 2019 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4091
Abstract: Mitochondrial dysfunction is considered to be an important component of many metabolic diseases yet there is no reliable imaging biomarker for monitoring mitochondrial damage in vivo. A large prior literature on inter‐conversion of β‐hydroxybutyrate and… read more here.
Keywords: mitochondrial redox; redox state; acetoacetate; hydroxybutyrate ... See more keywords
Improved detection of lactate and β‐hydroxybutyrate using MEGA‐sLASER at 3 T
Sign Up to like & getrecommendations! Published in 2019 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4100
Abstract: Lactate and β‐hydroxybutyrate are important MRS‐visible biomarkers for the energy metabolism of the human brain. A major obstacle for their unambiguous detection and quantification in vivo is their inherently low concentration and spectral overlap with… read more here.
Keywords: mega slaser; detection; lactate hydroxybutyrate; hydroxybutyrate ... See more keywords
Chemical Recycling of Bio-based Poly(3-hydroxybutyrate) Wastes Under Methanolysis Condition Catalyzed by Fe-Containing Magnetic Ionic Liquid
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Polymers and the Environment"
DOI: 10.1007/s10924-018-1347-8
Abstract: An efficient method for chemical recycling of bio-based polymers Poly(3-hydroxybutyrate) (PHB) wastes was established from the perspective of biorefinery. This methanolysis reaction archived successfully transformation PHB into corresponding monomer catalyzed by imidazolium-based Fe-containing ionic liquid,… read more here.
Keywords: ionic liquid; liquid; chemical recycling; hydroxybutyrate ... See more keywords
Efficient synthesis of the ketone body ester (R)-3-hydroxybutyryl-(R)-3-hydroxybutyrate and its (S,S) enantiomer.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.07.010
Abstract: The ketone body ester (R)-3-hydroxybutyryl-(R)-3-hydroxybutyrate and its (S,S) enantiomer were prepared in a short, operationally simple synthetic sequence from racemic β-butyrolactone. Enantioselective hydrolysis of β-butyrolactone with immobilized Candida antarctica lipase-B (CAL-B) results in (R)-β-butyrolactone and… read more here.
Keywords: ester hydroxybutyryl; ketone; ketone body; hydroxybutyrate ... See more keywords
Production of high molecular weight poly(3-hydroxybutyrate-co-4-hydroxybutyrate) copolymer by Cupriavidus malaysiensis USMAA1020 utilising substrate with longer carbon chain.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.04.148
Abstract: Long carbon chain alkanediols are used in the production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)], however these substrates possess high toxicity towards bacterial cells. This study demonstrated the effective utilisation of a long carbon chain alkanediol, namely 1,8-octanediol,… read more here.
Keywords: production; carbon; high molecular; molecular weight ... See more keywords
Metabolic engineering of Escherichia coli for the synthesis of the quadripolymer poly(glycolate-co-lactate-co-3-hydroxybutyrate-co-4-hydroxybutyrate) from glucose.
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2017.09.003
Abstract: Escherichia coli was metabolically engineered to effectively produce a series of biopolymers consisted of four types of monomers including glycolate, lactate, 3-hydroxybutyrate and 4-hydroxybutyrate from glucose as the carbon source. The biosynthetic route of novel… read more here.
Keywords: glycolate lactate; lactate hydroxybutyrate; hydroxybutyrate glucose; hydroxybutyrate ... See more keywords
Truncating the structure of lipopolysaccharide in Escherichia coli can effectively improve Poly-3-hydroxybutyrate production.
Sign Up to like & getrecommendations! Published in 2020 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.0c00071
Abstract: Poly-3-hydroxybutyrate is an environmentally friendly polymer with many promising applications, and can be produced in Escherichia coli cells after overexpressing the heterologous gene cluster phaCAB. In this study, we found that truncating the structure of… read more here.
Keywords: coli; poly hydroxybutyrate; hydroxybutyrate; pdxw phacab ... See more keywords
Unlocking the photobiological conversion of CO2 to (R)-3-hydroxybutyrate in cyanobacteria
Sign Up to like & getrecommendations! Published in 2018 at "Green Chemistry"
DOI: 10.1039/c8gc01208c
Abstract: Escalating concerns about CO2 emission from fossil fuel utilization and environmental pollution from fossil-derived plastic waste call for the sustainable production and utilization of renewable biodegradable plastic materials. Polyhydroxyalkanoates (PHAs) are biodegradable and biocompatible thermoplastics… read more here.
Keywords: production; conversion co2; unlocking photobiological; hydroxybutyrate ... See more keywords
Visible-light driven 3-hydroxybutyrate synthesis from CO2 and acetone with the hybrid system of photocatalytic NADH regeneration and multi-biocatalysts.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03660f
Abstract: Poly-3-hydroxybutyrate (PHB)-derived plastics are polymer materials with excellent biodegradability, being insoluble in water and relatively resistant to hydrolysis. There is a need for a method capable of synthesizing 3-hydroxybutyrate, a monomer of PHB, from a… read more here.
Keywords: system; driven hydroxybutyrate; acetone; hydroxybutyrate ... See more keywords
Influence of Exogenous β-Hydroxybutyrate on Walking Economy and Rating of Perceived Exertion
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Dietary Supplements"
DOI: 10.1080/19390211.2018.1471562
Abstract: ABSTRACT This study investigates the effect of a supplementary ketone, β-hydroxybutyrate (BHB), on walking economy and ratings of perceived exertion in apparently healthy individuals. In a repeated-measures, crossover design, ten non–aerobically trained participants (three males;… read more here.
Keywords: walking economy; rating perceived; hydroxybutyrate; perceived exertion ... See more keywords
Methyl-4-hydroxybutyrate and Ethyl-4-hydroxybutyrate as Potential Markers for Simultaneous Consumption of GHB/GBL and Alcohol: Preliminary Investigations.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of analytical toxicology"
DOI: 10.1093/jat/bkaa096
Abstract: γ-Hydroxybutyric acid (GHB) and its corresponding lactone γ-butyrolactone (GBL) are misused as knock out (k.o.) drugs. The short detection window and the major inter- and intra-individual variations of endogenous GHB concentrations in commonly used matrices… read more here.
Keywords: ethyl hydroxybutyrate; ghb gbl; hydroxybutyrate;