Phase I metabolites (organic acids) of gamma-hydroxybutyric acid -validated quantification by GC-MS and description of endogenous concentration ranges.
Sign Up to like & getrecommendations! Published in 2020 at "Drug testing and analysis"
DOI: 10.1002/dta.2820
Abstract: Gamma hydroxybutyric acid (GHB) is known as a sedative drug used in Drug Facilitated Crimes. Its detection window is very short. GHB undergoes intensive phase I metabolism to organic acids (glycolic acid, succinic acid, dihydroxy… read more here.
Keywords: gamma hydroxybutyric; hydroxybutyric acid; dihydroxy butyric; acid ... See more keywords
Fatty acid esters as novel metabolites of γ-hydroxybutyric acid (GHB): A preliminary investigation.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3213
Abstract: γ-Hydroxybutyric acid (GHB) is a substance frequently abused as a knock-out agent. Because of possible amnesia experienced by victims of GHB exposure and the short detection time of GHB in biological samples, the proof of… read more here.
Keywords: ghb pal; acid esters; ghb; hydroxybutyric acid ... See more keywords
Production of (R)-3-hydroxybutyric acid from methane by in vivo depolymerization of polyhydroxybutyrate in Methylocystis parvus OBBP.
Sign Up to like & getrecommendations! Published in 2022 at "Bioresource technology"
DOI: 10.1016/j.biortech.2022.127141
Abstract: Methylocystis parvus OBBP accumulates polyhydroxybutyrate (PHB) using methane as the sole carbon and energy source. In this work, the feasibility of producing (R)-3-hydroxybutyric acid (R3HBA) via intracellularly accumulated PHB through depolymerization (in-vivo) was investigated. Results… read more here.
Keywords: methylocystis parvus; hydroxybutyric acid; depolymerization; parvus obbp ... See more keywords
Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pharmaceutical Analysis"
DOI: 10.1016/j.jpha.2019.11.003
Abstract: Liver injury caused by acetaminophen (AP) overdose is a leading public health problem. Although AP-induced liver injury is well recognized as the formation of N-acetyl-p-benzoquinone (NAPQI), a toxic metabolite of AP, resulting in cell damage,… read more here.
Keywords: induced liver; hydroxybutyric acid; gut microbiota; liver injury ... See more keywords
The relationship of asprosin with β-hydroxybutyric acid and postpartum disorders in cows.
Sign Up to like & getrecommendations! Published in 2022 at "Acta veterinaria Hungarica"
DOI: 10.1556/004.2022.00002
Abstract: The aim of the present study was to determine asprosin levels in cows, the relationship of this hormone with postpartum disorders and β-hydroxybutyric acid, and also the potential of asprosin to be a marker for… read more here.
Keywords: hydroxybutyric acid; asprosin; asprosin hydroxybutyric; postpartum disorders ... See more keywords
Daily Intake of D-β-Hydroxybutyric Acid (D-BHB) Reduces Body Fat in Japanese Adult Participants: A Randomized, Double-Blind, Placebo-Controlled Study.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of nutritional science and vitaminology"
DOI: 10.3177/jnsv.69.121
Abstract: Currently, there is considerable interest in ketone metabolism owing to the benefits for human health. Conventionally, strict dietary restrictions on carbohydrates are required to increase plasma ketone levels, while supplementation with D-β-hydroxybutyric acid (D-BHB) can… read more here.
Keywords: daily intake; acid bhb; hydroxybutyric acid; body fat ... See more keywords
Interaction between γ-Hydroxybutyric Acid and Ethanol: A Review from Toxicokinetic and Toxicodynamic Perspectives
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DOI: 10.3390/metabo13020180
Abstract: Gamma-hydroxybutyric acid (GHB) is a potent, short-acting central nervous system depressant as well as an inhibitory neurotransmitter or neuromodulator derived from gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter. The sodium salt of GHB, sodium oxybate,… read more here.
Keywords: ghb ethanol; ghb; ethanol; hydroxybutyric acid ... See more keywords
2 Hydroxybutyric Acid-Producing Bacteria in Gut Microbiome and Fusobacterium nucleatum Regulates 2 Hydroxybutyric Acid Level In Vivo
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DOI: 10.3390/metabo13030451
Abstract: 2-hydroxybutyric acid (2HB) serves as an important regulatory factor in a variety of diseases. The circulating level of 2HB in serum is significantly higher in multiple diseases, such as cancer and type 2 diabetes (T2D).… read more here.
Keywords: producing bacteria; fusobacterium nucleatum; hydroxybutyric acid;
Mechanical Properties of 3-Hydroxybutyric Acid-Induced Vesicles
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DOI: 10.3390/molecules28062742
Abstract: The vesicle mechanical behaviors were studied upon its exposure to 3-hydroxybutyric acid using an atomic force microscope (AFM). Dipalmitoylphosphatidylcholine (DPPC) and 3-hydroxybutyric acid were used to manufacture the vesicles at their desired ratio. The deflection… read more here.
Keywords: properties hydroxybutyric; acid induced; induced vesicles; hydroxybutyric acid ... See more keywords