Facile Fabrication of 10-Hydroxycamptothecin-Backboned Amphiphilic Polyprodrug with Precisely Tailored Drug Loading Content for Controlled Release.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00238
Abstract: Polymeric prodrugs with precisely controlled drug loading content (DLC) and rapid intracellular destabilization generally require complicated chemistry that hinders large-scale manufacture. For this purpose, we reported in this study a facile construction of reduction-sensitive amphiphilic… read more here.
Keywords: drug loading; loading content; chemistry; drug ... See more keywords
Nanocochleates as the Potential Delivery Systems for Oral Antitumor of Hydroxycamptothecin.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2018.2572
Abstract: It remains a major challenge to improve the oral antitumor efficacy of hydroxycamptothecin (HCPT). The aim of this study was to develop the oral HCPT formulation via nanocochleates technology. After HCPT was incorporated into calcium… read more here.
Keywords: hcpt; delivery; loaded nanocochleates; hcpt loaded ... See more keywords