Colitis Alters Oxysterol Metabolism and is Affected by 4&bgr;-Hydroxycholesterol Administration
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjy157
Abstract: Background and Aims Inflammatory bowel diseases [IBD] represent a challenging health issue with a complex aetiology involving genetic and environmental parameters. Although our understanding of the pathophysiology of IBD has improved, much remains to be… read more here.
Keywords: hydroxycholesterol; colitis alters; alters oxysterol; oxysterol metabolism ... See more keywords
Anti-PCSK 9 antibodies increase the ratios of the brain-specific oxysterol 24S-hydroxycholesterol to cholesterol and to 27-hydroxycholesterol in the serum.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.14841
Abstract: AIM The serum ratios of the brain-specific oxysterol 24S-hydroxycholesterol (24S-OHC) to cholesterol and to 27-OHC reflect brain cholesterol turnover. We studied the effect of proprotein convertase subtilisin/kexin type 9 monoclonal antibodies (PCSK9ab) that enhance LDL-receptor… read more here.
Keywords: hydroxycholesterol; cholesterol; serum; 24s ohc ... See more keywords
Circulating 27-hydroxycholesterol and Risk of Colorectal Adenomas and Serrated Polyps
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DOI: 10.1158/1940-6207.capr-20-0414
Abstract: This study found that plasma concentration of 27-hydroxycholesterol, a metabolite of cholesterol that regulates lipid metabolism and acts as a selective estrogen receptor modulator, is associated with the risk of developing precursor lesions for colorectal… read more here.
Keywords: polyps circulating; risk; circulating ohc; hydroxycholesterol ... See more keywords
Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion Remodeling
Sign Up to like & getrecommendations! Published in 2022 at "Circulation"
DOI: 10.1161/circulationaha.122.059062
Abstract: Background: Cross-talk between sterol metabolism and inflammatory pathways has been demonstrated to significantly affect the development of atherosclerosis. Cholesterol biosynthetic intermediates and derivatives are increasingly recognized as key immune regulators of macrophages in response to… read more here.
Keywords: ch25h; macrophage derived; hydroxycholesterol; atherosclerosis ... See more keywords
25-Hydroxycholesterol exacerbates vascular leak during acute lung injury
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.155448
Abstract: Cholesterol-25-hydroxylase (CH25H), the biosynthetic enzyme for 25-hydroxycholesterol (25HC), is most highly expressed in the lung, but its role in lung biology is poorly defined. Recently, we reported that Ch25h is induced in monocyte-derived macrophages recruited… read more here.
Keywords: ch25h; lung injury; hydroxycholesterol; leak ... See more keywords
Maternal 27-hydroxycholesterol concentrations during the course of pregnancy and in pregnancy pathologies
Sign Up to like & getrecommendations! Published in 2017 at "BMC Pregnancy and Childbirth"
DOI: 10.1186/s12884-017-1287-7
Abstract: BackgroundThe oxysterol 27-hydroxycholesterol (27-OHC) plays an important role in the regulation of cholesterol homeostasis. Pregnancy pathologies like preeclampsia (PE), HELLP-syndrome (HELLP), intrauterine growth restriction (IUGR) and intrahepatic cholestasis in pregnancy (ICP) are linked to disturbances… read more here.
Keywords: hydroxycholesterol; pregnancy; course pregnancy; ohc ... See more keywords
Esterification of 4β-hydroxycholesterol and other oxysterols in human plasma occurs independently of LCAT
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Lipid Research"
DOI: 10.1194/jlr.ra119000512
Abstract: The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking. Here, we measured both free and FA-esterified forms of… read more here.
Keywords: healthy volunteers; lcat; esterification; hydroxycholesterol ... See more keywords
25-Hydroxycholesterol is involved in the pathogenesis of amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14416
Abstract: This study aimed to evaluate the levels of three major hydroxycholesterols (24-, 25-, and 27-hydroxycholesterols) in the serum and cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS), as well as to show their… read more here.
Keywords: hydroxycholesterol; involved pathogenesis; pathogenesis; amyotrophic lateral ... See more keywords
Investigation on the synthesis of 24-(R)-hydroxycholesterol
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DOI: 10.2139/ssrn.4363511
Abstract: A facile and novel strategy has been developed for synthesis of 24-(R)-hydroxycholesterol, a key intermediate of tacalcitol, starting from 24-dehydrocholesterol in seven steps with 48.2% overall yield and high diastereomer ratio. Photocatalytic oxidation of olefins… read more here.
Keywords: synthesis hydroxycholesterol; hydroxycholesterol; investigation synthesis;
Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.815775
Abstract: Many species of bacteria produce toxins such as cholesterol-dependent cytolysins that form pores in cell membranes. Membrane pores facilitate infection by releasing nutrients, delivering virulence factors, and causing lytic cell damage - cytolysis. Oxysterols are… read more here.
Keywords: pore forming; hydroxycholesterol; pyolysin; cells pore ... See more keywords
Oxysterols as Reliable Markers of Quality and Safety in Cholesterol Containing Food Ingredients and Products
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.853460
Abstract: Cholesterol is a lipid of high nutritional value that easily undergoes oxidation through enzymatic and non-enzymatic pathways, leading to a wide variety of cholesterol oxidation products (COPs), more commonly named oxysterols. The major oxysterols found… read more here.
Keywords: food; quality safety; cholesterol; markers quality ... See more keywords