Facile synthesis and docking studies of 7-hydroxyflavanone isoxazoles and acrylates as potential anti-microbial agents
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-019-02476-5
Abstract: The present study is aimed to synthesize the novel 7-hydroxyflavanone derived compounds and to assess their biological activity. Two series of compounds such as 2-phenyl-7-((3-phenylisoxazol-5-yl)methoxy)chroman-4-ones ( 6a–h ) and 4-oxo-2-phenylchroman-7-yl acrylates ( 8a–k ) were… read more here.
Keywords: docking studies; anti microbial; hydroxyflavanone; isoxazoles acrylates ... See more keywords
Efficacy of 2-Hydroxyflavanone in Rodent Models of Pain and Inflammation: Involvement of Opioidergic and GABAergic Anti-Nociceptive Mechanisms
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DOI: 10.3390/molecules27175431
Abstract: The current work examined the pharmacological potential of a selected flavanone derivative 2-hydroxyflavanone as a promising remedy for the treatment and management of pain. The selected flavanone derivative (2-HF) was evaluated for its analgesic and… read more here.
Keywords: opioidergic gabaergic; hydroxyflavanone; anti nociceptive; pain ... See more keywords
Targeting Anti-Inflammatory Pathways to Treat Diabetes-Induced Neuropathy by 6-Hydroxyflavanone
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DOI: 10.3390/nu15112552
Abstract: It is evident that inflammation and metabolic syndrome instigated by diabetes mellitus can precipitate diabetes-induced neuropathy (DIN) and pain. In order to find an effective therapeutic method for diabetes-related problems, a multi-target-directed ligand model was… read more here.
Keywords: cox; hydroxyflavanone; induced neuropathy; anti inflammatory ... See more keywords