Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07563-6
Abstract: Lysine degradation has remained elusive in many organisms including Escherichia coli. Here we report catabolism of lysine to succinate in E. coli involving glutarate and L-2-hydroxyglutarate as intermediates. We show that CsiD acts as an… read more here.
Keywords: glutarate hydroxyglutarate; lysine degradation; hydroxyglutarate;
L-2-Hydroxyglutarate Protects Against Cardiac Injury via Metabolic Remodeling
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.122.321227
Abstract: Background: L-2-hydroxyglutarate (L2HG) couples mitochondrial and cytoplasmic energy metabolism to support cellular redox homeostasis. Under oxygen-limiting conditions, mammalian cells generate L2HG to counteract the adverse effects of reductive stress induced by hypoxia. Very little is… read more here.
Keywords: l2hg accumulation; ischemia; hydroxyglutarate; spectroscopy ... See more keywords
Fermentative Production of l-2-Hydroxyglutarate by Engineered Corynebacterium glutamicum via Pathway Extension of l-Lysine Biosynthesis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.630476
Abstract: l-2-hydroxyglutarate (l-2HG) is a trifunctional building block and highly attractive for the chemical and pharmaceutical industries. The natural l-lysine biosynthesis pathway of the amino acid producer Corynebacterium glutamicum was extended for the fermentative production of… read more here.
Keywords: production; lysine biosynthesis; hydroxyglutarate; fermentative production ... See more keywords
Renal oncometabolite L-2-hydroxyglutarate imposes a block in kidney tubulogenesis: Evidence for an epigenetic basis for the L-2HG-induced impairment of differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.932286
Abstract: 2-Hydroxyglutarate (2HG) overproducing tumors arise in a number of tissues, including the kidney. The tumorigenesis resulting from overproduced 2HG has been attributed to the ability of 2HG alter gene expression by inhibiting α-ketoglutarate (αKG)-dependent dioxygenases,… read more here.
Keywords: tubulogenesis; hydroxyglutarate; kidney; renal oncometabolite ... See more keywords
Metabolic Rewiring and the Characterization of Oncometabolites
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13122900
Abstract: Simple Summary Oncometabolites are produced by cancer cells and assist the cancer to proliferate and progress. Oncometabolites occur as a result of mutated enzymes in the tumor tissue or due to hypoxia. These processes result… read more here.
Keywords: metabolic rewiring; oncometabolites fumarate; hydroxyglutarate; fumarate succinate ... See more keywords
Quantitative analysis of 2-hydroxyglutarate as a controversial oncometabolite in malignant gliomas.
Sign Up to like & getrecommendations! Published in 2020 at "Neoplasma"
DOI: 10.4149/neo_2020_200302n216
Abstract: There is a great effort to connect the accumulation of 2-hydroxyglutarate (2-HG) oncometabolite with cellular onco-epigenetic status and subsequently predict the prognoses of glioma patients. In this observational study, the concentrations of D- and L-… read more here.
Keywords: controversial oncometabolite; hydroxyglutarate controversial; tumor tissue; quantitative analysis ... See more keywords
Oncometabolite D-2-Hydroxyglutarate enhances gene silencing through inhibition of specific H3K36 histone demethylases
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.22451
Abstract: Certain mutations affecting central metabolism cause accumulation of the oncometabolite D-2-hydroxyglutarate which promotes progression of certain tumors. High levels of D-2-hydroxyglutarate inhibit the TET family of DNA demethylases and Jumonji family of histone demethylases and… read more here.
Keywords: histone demethylases; inhibition; hydroxyglutarate; gene ... See more keywords