New Insights into Tolytoxin Effect in Human Cancer Cells: Apoptosis Induction and the Relevance of Hydroxyl Substitution of Its Macrolide Cycle on Compound Potency
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DOI: 10.1002/cbic.202100489
Abstract: Scytophycins, including tolytoxin, represent a class of actin disrupting macrolides with strong antiproliferative effects on human cells. Despite intense research, little attention has been paid to scytophycin‐induced cell death or the structural features affecting its… read more here.
Keywords: hydroxyl substitution; potency; effect; new insights ... See more keywords