Vitamin D–Dependent Rickets Type 1B (25‐Hydroxylase Deficiency): A Rare Condition or a Misdiagnosed Condition?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3181
Abstract: Vitamin D requires a two‐step activation by hydroxylation: The first step is catalyzed by hepatic 25‐hydroxylase (CYP2R1, 11p15.2) and the second one is catalyzed by renal 1α‐hydroxylase (CYP27B1, 12q13.1), which produces the active hormonal form… read more here.
Keywords: hydroxylase; vitamin dependent; condition; deficiency ... See more keywords
Characterization of CyrI, the hydroxylase involved in the last step of cylindrospermopsin biosynthesis: Binding studies, site-directed mutagenesis and stereoselectivity.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.04.007
Abstract: Cylindrospermopsin, a cytotoxin from cyanobacteria, is biosynthesized by a complex pathway, which involves CyrI, an iron and 2-oxoglutarate dependent hydroxylase that transforms 7-deoxy-cylindrospermopsin into cylindrospermopsin and its epimer, 7-epi-cylindrospermopsin, in the last step. The activity… read more here.
Keywords: cyri; hydroxylase; cylindrospermopsin; stereoselectivity ... See more keywords
Natural diversity of FAD-dependent 4-hydroxybenzoate hydroxylases.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108820
Abstract: 4-Hydroxybenzoate 3-hydroxylase (PHBH) is the most extensively studied group A flavoprotein monooxygenase (FPMO). PHBH is almost exclusively found in prokaryotes, where its induction, usually as a consequence of lignin degradation, results in the regioselective formation… read more here.
Keywords: hydroxybenzoate; hydroxylase; hydroxybenzoate hydroxylase; fad dependent ... See more keywords
Perte de sel dans les blocs en 21-hydroxylase : les précurseurs stéroïdiens et les métabolites mineurs aggravent la symptomatologie
Sign Up to like & getrecommendations! Published in 2018 at "Annales d'Endocrinologie"
DOI: 10.1016/j.ando.2018.06.113
Abstract: L’hyperplasie congenitale des surrenales (HCS) est une maladie autosomique recessive grave due principalement a un deficit en 21-hydroxylase et responsable d’une insuffisance surrenalienne avec defaut de secretion de cortisol et d’aldosterone. L’HCS peut etre decelee… read more here.
Keywords: les blocs; hydroxylase; perte sel; dans les ... See more keywords
Désordre de développement sexuel révélant un bloc en 11b hydroxylase non classique
Sign Up to like & getrecommendations! Published in 2018 at "Annales d'Endocrinologie"
DOI: 10.1016/j.ando.2018.06.667
Abstract: Introduction L’hyperplasie congenitale des surrenales (HCS) par bloc enzymatique en 11β hydroxylase est une pathologie a transmission autosomique recessive. Nous rapportons une observation particuliere d’un desordre de developpement sexuel. Observation Le tableau clinique associe des… read more here.
Keywords: sordre veloppement; hydroxylase; bloc; veloppement sexuel ... See more keywords
Hyperandrogénie féminine : pensez aux blocs enzymatiques !
Sign Up to like & getrecommendations! Published in 2018 at "Annales d'Endocrinologie"
DOI: 10.1016/j.ando.2018.06.683
Abstract: Introduction L’hyperandrogenie est un motif de consultation banal en endocrinologie, gynecologie ou dermatologie. Chez un pourcentage de patientes non negligeable, une maladie genetique autosomique recessive, deficit en 21-hydroxylase non classique, en est responsable. Observation Nous… read more here.
Keywords: hydroxylase; hyperandrog nie; nie minine; genetique ... See more keywords
Infertilité primaire révélant un bloc en 21 hydroxylase : à propos d’un cas
Sign Up to like & getrecommendations! Published in 2018 at "Annales d'Endocrinologie"
DOI: 10.1016/j.ando.2018.06.808
Abstract: Introduction L’hyperplasie congenitale des surrenales par bloc en 21 hydroxylase a revelation tardive est une maladie a transmission autosomique recessive dont la presentation usuelle est une virilisation tardive para ou post pubertaire. Nous rapportons le cas… read more here.
Keywords: hydroxylase; des surrenales; cas; bloc hydroxylase ... See more keywords
Tyrosine hydroxylase in the ventral tegmental area of rams with high or low libido-A role for dopamine.
Sign Up to like & getrecommendations! Published in 2017 at "Animal reproduction science"
DOI: 10.1016/j.anireprosci.2017.10.019
Abstract: Dopamine synthesis in the ventral tegmental area (VTA) is necessary for the reinforcement of sexual behavior. The objective of this study determined if sexual stimuli initiates reward, and whether reward is attenuated in sexually inactive… read more here.
Keywords: hydroxylase; exposure; dopamine; ventral tegmental ... See more keywords
Phenol Hydroxylase from Pseudomonas sp. KZNSA: Purification, Characterization and Prediction of Three-Dimensional Structure.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.09.224
Abstract: A 61.3 kDa Phenol hydroxylase (PheA) was purified and characterized from Pseudomonas sp. KZNSA (PKZNSA). Cell free extract of the isolate grown in mineral salt medium supplemented with 600 ppm phenol showed 21.58 U/mL of… read more here.
Keywords: hydroxylase; phea; pseudomonas kznsa; phenol ... See more keywords
Assessment of electrocatalytic hydroxylase activity of cytochrome P450 3A4 (CYP3A4) by means of derivatization of 6β-hydroxycortisol by sulfuric acid for fluorimetric assay.
Sign Up to like & getrecommendations! Published in 2019 at "Talanta"
DOI: 10.1016/j.talanta.2018.12.041
Abstract: We used rapid one-step derivatization of 6β-hydroxylated hydrocortisone by sulfuric acid for fluorimetric determination of CYP3A4-dependent hydroxylase reaction in the electrochemical system. We have shown that CYP3A4 substrate - hydrocortisone - and its 6β-hydroxylated product… read more here.
Keywords: hydroxylase; sulfuric acid; hydroxycortisol; cyp3a4 ... See more keywords
Structure-Guided Reprogramming of a Hydroxylase To Halogenate Its Small Molecule Substrate.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.6b01173
Abstract: Enzymatic installation of chlorine/bromine into unactivated carbon centers provides a versatile, selective, and environmentally friendly alternative to chemical halogenation. Iron(II) and 2-(oxo)-glutarate (FeII/2OG)-dependent halogenases are powerful biocatalysts that are capable of cleaving aliphatic C-H bonds… read more here.
Keywords: hydroxylase; small molecule; molecule substrate; structure ... See more keywords