Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors.
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DOI: 10.1021/acs.jmedchem.1c01898
Abstract: Cholesterol 24-hydroxylase (CH24H or CYP46A1) is a brain-specific cytochrome P450 enzyme that metabolizes cholesterol into 24S-hydroxycholesterol (24HC) for regulating brain cholesterol homeostasis. For the development of a novel and potent CH24H inhibitor, we designed and… read more here.
Keywords: cholesterol hydroxylase; ch24h; pyridine derivatives; hydroxylase ch24h ... See more keywords