miR‐21 contributes to renal protection by targeting prolyl hydroxylase domain protein 2 in delayed ischaemic preconditioning
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DOI: 10.1111/nep.12787
Abstract: Upregulation of miR‐21 in renal ischaemic preconditioning (IPC) was associated with increased hypoxia inducible factor (HIF)‐1α expression. Hypoxic induction of HIF‐1α is mediated by inhibition of prolyl hydroxylase domain protein 2 (PHD2) .We hypothesized that… read more here.
Keywords: prolyl hydroxylase; hydroxylase domain; domain protein; ischaemic preconditioning ... See more keywords
Prolyl Hydroxylase Domain Inhibitor Protects against Metabolic Disorders and Associated Kidney Disease in Obese Type 2 Diabetic Mice.
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DOI: 10.1681/asn.2019060582
Abstract: BACKGROUND Prolyl hydroxylase domain (PHD) inhibitors, which stimulate erythropoietin production through the activation of hypoxia-inducible factor (HIF), are novel therapeutic agents used for treating renal anemia. Several PHD inhibitors, including enarodustat, are currently undergoing phase… read more here.
Keywords: mice; prolyl hydroxylase; hydroxylase domain; metabolic disorders ... See more keywords