Ferritin heavy chain controls the HIF-driven hypoxic response by activating the asparaginyl hydroxylase FIH.
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DOI: 10.1016/j.bbrc.2018.03.173
Abstract: Hypoxia-inducible factor 1 (HIF-1) is a key player in cellular response to hypoxia. The stability and transcriptional activity of this protein are oxygen-dependently regulated by the prolyl hydroxylases PHD1-3 and the asparaginyl hydroxylase FIH. Recently,… read more here.
Keywords: ferritin heavy; hif; asparaginyl hydroxylase; heavy chain ... See more keywords