Generation of tryptophan hydroxylase 2 gene knockout pigs by CRISPR/Cas9-mediated gene targeting
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DOI: 10.7555/jbr.31.20170026
Abstract: Unbalanced brain serotonin (5-HT) levels have implications in various behavioral abnormalities and neuropsychiatric disorders. The biosynthesis of neuronal 5-HT is regulated by the rate-limiting enzyme, tryptophan hydroxylase-2 (TPH2). In the present study, the clustered regularly… read more here.
Keywords: hydroxylase gene; generation tryptophan; crispr cas9; tryptophan hydroxylase ... See more keywords