Comparison of the Hydroxylase Inhibitor Dimethyloxalylglycine and the Iron Chelator Deferoxamine in Diabetic and Aged Wound Healing
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DOI: 10.1097/prs.0000000000003072
Abstract: Background: A hallmark of diabetes mellitus is the breakdown of almost every reparative process in the human body, leading to critical impairments of wound healing. Stabilization and activity of the transcription factor hypoxia-inducible factor (HIF)-1&agr;… read more here.
Keywords: wound healing; deferoxamine; hydroxylase inhibitor; dimethyloxalylglycine ... See more keywords
Osilodrostat: 11β-hydroxylase inhibitor for treatment of Cushing's disease.
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DOI: 10.1358/dot.2020.56.10.3182908
Abstract: Osilodrostat was synthesized in a search for a drug that would inhibit the synthesis of aldosterone, with the aim to discover a new approach for treating hypertension. However, early clinical trials revealed that the doses… read more here.
Keywords: cushing disease; inhibitor; osilodrostat hydroxylase; hydroxylase inhibitor ... See more keywords