6α-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice
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DOI: 10.1136/gutjnl-2021-326541
Abstract: Objective Dietary fibres are essential for maintaining microbial diversity and the gut microbiota can modulate host physiology by metabolising the fibres. Here, we investigated whether the soluble dietary fibre oligofructose improves host metabolism by modulating… read more here.
Keywords: metabolism; tgr5; western style; hydroxylated bile ... See more keywords
Insulin Prevents Hypercholesterolemia by Suppressing 12α-Hydroxylated Bile Acids
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DOI: 10.1161/circulationaha.120.045373
Abstract: Background: The risk of cardiovascular disease in type 1 diabetes remains extremely high, despite marked advances in blood glucose control and even the widespread use of cholesterol synthesis inhibitors. Thus, a deeper understanding of insulin… read more here.
Keywords: cholesterol; insulin; hydroxylated bile; cholesterol absorption ... See more keywords