Synthesis and Biological Evaluation of Hydroxylated Monocarbonyl Curcumin Derivatives as Potential Inducers of Neprilysin Activity
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DOI: 10.3390/biomedicines9080955
Abstract: Background: Alzheimer’s disease (AD) involves impairment of Aβ clearance. Neprilysin (NEP) is the most efficient Aβ peptidase. Enhancement of the activity or expression of NEP may provide a prominent therapeutic strategy against AD. Aims: Ten… read more here.
Keywords: curcumin derivatives; monocarbonyl curcumin; hydroxylated monocarbonyl; synthesis biological ... See more keywords