A peroxodiiron(III) intermediate mediating both N-hydroxylation steps in biosynthesis of the N-nitrosourea pharmacophore of streptozotocin by SznF.
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DOI: 10.1021/jacs.0c03431
Abstract: The alkylating warhead of the antineoplastic drug streptozotocin (SZN) contains an N-nitrosourea moiety constructed from Nω-methyl-L-arginine (L-NMA) by the multi-domain metalloenzyme SznF. The enzyme's central heme-oxygenase-like (HO-like) domain sequentially hydroxylates Nδ and Nω' of L-NMA.… read more here.
Keywords: iii; sznf; iii intermediate; hydroxylation steps ... See more keywords