Stereoselective synthesis of 4-hydroxymethyl-1,3-oxazolidin-2-one derivatives from novel 2-hydroxymethylaziridines
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DOI: 10.1080/00397911.2018.1490771
Abstract: Abstract A stereoselective and simple method for the synthesis of trans-2-hydroxymethyl-N-alkyl-1,3-oxazolidin-2-ones is described. The synthesis involved the reduction of trans-aziridine-2-carboxylates with LiAlH4, followed by a ring opening and a cyclization reaction in the presence of… read more here.
Keywords: one derivatives; stereoselective synthesis; oxazolidin one; hydroxymethyl oxazolidin ... See more keywords