Sensitive detection of hydroxymethylcytosine levels in normal and neoplastic cells and tissues
Sign Up to like & getrecommendations! Published in 2019 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201800523
Abstract: A new sensitive analytical method using capillary electrophoresis with laser induced fluorescence (CE‐LIF) was applied for the simultaneous detection of DNA methylation and hydroxymethylation levels in human cancers of different origin. DNA hydroxymethylation, measured as… read more here.
Keywords: detection; 5hmc levels; detection hydroxymethylcytosine; hydroxymethylation ... See more keywords
DNA hydroxymethylation of colorectal primary carcinoma and its association with survival
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.24978
Abstract: A total of 71 cases of colorectal carcinoma with hepatic metastasis were enrolled from the Department of Pathology of SIR RUN RUN SHAW Hospital. Paired primary tumors, hepatic metastases, and normal mucosa samples were collected… read more here.
Keywords: primary carcinoma; carcinoma; hydroxymethylation; dna hydroxymethylation ... See more keywords
Hypo-Hydroxymethylation of Nobox is Associated with Ovarian Dysfunction in Rat Offspring Exposed to Prenatal Hypoxia
Sign Up to like & getrecommendations! Published in 2022 at "Reproductive Sciences"
DOI: 10.1007/s43032-022-00866-6
Abstract: Prenatal hypoxia (PH) is a common feature of a suboptimal intrauterine environment affecting the development of fetuses. Whether PH leads to abnormal ovary development is not yet clear. This study investigated ovarian function in offspring… read more here.
Keywords: prenatal hypoxia; hypo hydroxymethylation; offspring exposed; hydroxymethylation ... See more keywords
TET1 and 5-Hydroxymethylation Preserve the Stem Cell State of Mouse Trophoblast
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2020.04.009
Abstract: Summary The ten-eleven translocation factor TET1 and its conferred epigenetic modification 5-hydroxymethylcytosine (5hmC) have important roles in maintaining the pluripotent state of embryonic stem cells (ESCs). We previously showed that TET1 is also essential to… read more here.
Keywords: state; cell state; hydroxymethylation; stem cell ... See more keywords
Quantification of Global DNA Hydroxymethylation Level Using UHRF2 SRA-Luciferase Based on Bioluminescence Resonance Energy Transfer.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c05619
Abstract: 5-Methylcytosine (5mC) plays an important role in the regulation of gene expression. Ten-eleven translocation (TET) continuously oxidizes 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). High levels of 5hmC are found in the brain… read more here.
Keywords: hydroxymethylation level; dna; hydroxymethylation; uhrf2 sra ... See more keywords
Epigenetic biomarkers of cold and heat syndromes of rheumatoid arthritis: Combining DNA hydroxymethylation and mRNA‐sequencing
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Rheumatic Diseases"
DOI: 10.1111/1756-185x.14480
Abstract: Syndrome (Zheng in Mandarin Chinese) is the induction of disease attributes in the theory of traditional Chinese medicine (TCM). This is often used to explain why patients with the same disease show different symptoms. Cold… read more here.
Keywords: epigenetic biomarkers; hydroxymethylation; cold heat; heat syndromes ... See more keywords
A study on DNA hydroxymethylation in Kaposi sarcoma and cutaneous angiosarcoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.16444
Abstract: Hydroxymethylation studies on cutaneous vascular tumours, such as classic Kaposi sarcoma (CKS) and cutaneous angiosarcoma (CAS), have not been reported yet. We aimed to investigate the expression of 5-methylcytosine (5-mc), 5-hydroxymethylcytosine (5-hmc), ten-eleven translocation enzyme… read more here.
Keywords: kaposi sarcoma; hydroxymethylation; cutaneous angiosarcoma; study dna ... See more keywords
Differential olfactory bulb methylation and hydroxymethylation are linked to odor location memory bias in injured mice
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Pain"
DOI: 10.1177/1744806919873475
Abstract: Chronic pain is often linked to comorbidities such as anxiety and cognitive dysfunction, alterations that are reflected in brain plasticity in regions such as the prefrontal cortex and the limbic area. Despite the growing interest… read more here.
Keywords: hydroxymethylation; methylation; injured mice; olfactory bulb ... See more keywords
Prenatal Exposure to Mercury: Associations with Global DNA Methylation and Hydroxymethylation in Cord Blood and in Childhood
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Health Perspectives"
DOI: 10.1289/ehp1467
Abstract: BACKGROUND Mercury is a global pollutant, and prenatal exposure is associated with adverse health effects. To date, no studies have evaluated the association between prenatal mercury exposure and DNA hydroxymethylation, an epigenetic modification important for… read more here.
Keywords: cord blood; dna; exposure; hydroxymethylation ... See more keywords
Role of TET Dioxygenases and DNA Hydroxymethylation in Bisphenols-Stimulated Proliferation of Breast Cancer Cells
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Health Perspectives"
DOI: 10.1289/ehp5862
Abstract: Background: Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor targeting estrogen receptors (ERs), has been implicated in the promotion of breast cancer. Perinatal exposure of BPA could induce longitudinal alteration of DNA hydroxymethylation in imprinted… read more here.
Keywords: dna hydroxymethylation; cancer; hydroxymethylation; proliferation ... See more keywords
The hMeDIP-Seq identified INPP4A as a novel biomarker for eosinophilic chronic rhinosinusitis with nasal polyps.
Sign Up to like & getrecommendations! Published in 2022 at "Epigenomics"
DOI: 10.2217/epi-2022-0053
Abstract: Background: Eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) is an endotype of chronic rhinosinusitis with nasal polyps characterized by more severe symptoms, a stronger association with asthma and a greater recurrence risk. It is unknown… read more here.
Keywords: nasal polyps; hydroxymethylation; chronic rhinosinusitis; rhinosinusitis nasal ... See more keywords