Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit
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DOI: 10.1038/mp.2017.239
Abstract: Low doses of ketamine trigger rapid and lasting antidepressant effects after one injection in treatment-resistant patients with major depressive disorder. Modulation of AMPA receptors (AMPARs) in the hippocampus and prefrontal cortex is suggested to mediate… read more here.
Keywords: plasticity mesolimbic; hydroxynorketamine; ketamine; synaptic plasticity ... See more keywords
Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine
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DOI: 10.1038/s41386-020-0714-z
Abstract: Enhancing stress resilience in at-risk populations could significantly reduce the incidence of stress-related psychiatric disorders. We have previously reported that the administration of (R,S)-ketamine prevents stress-induced depressive-like behavior in male mice, perhaps by altering α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic… read more here.
Keywords: hydroxynorketamine; ketamine; stress induced; stress ... See more keywords
(R,S)-ketamine and (2R,6R)-hydroxynorketamine differentially affect memory as a function of dosing frequency
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DOI: 10.1038/s41398-021-01685-0
Abstract: A single subanesthetic infusion of ketamine can rapidly alleviate symptoms of treatment-resistant major depression. Since repeated administration is required to sustain symptom remission, it is important to characterize the potential untoward effects of prolonged ketamine… read more here.
Keywords: hydroxynorketamine; dosing frequency; ketamine; function ... See more keywords
Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of (2R,6R)-hydroxynorketamine
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Psychopharmacology"
DOI: 10.1177/0269881118812095
Abstract: Background: (R,S)-ketamine has gained attention for its rapid-acting antidepressant actions in patients with treatment-resistant depression. However, widespread use of ketamine is limited by its side effects, abuse potential, and poor oral bioavailability. The ketamine metabolite,… read more here.
Keywords: oral bioavailability; hydroxynorketamine; bioavailability; antidepressant efficacy ... See more keywords