Asymmetric Transfer Hydrogenation of o-Hydroxyphenyl Ketones: Utilizing Directing Effects That Optimize the Asymmetric Synthesis of Challenging Alcohols.
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DOI: 10.1021/acs.orglett.0c01213
Abstract: A systematic range of o-hydroxyphenyl ketones were reduced under asymmetric transfer hydrogenation conditions using the C3-tethered catalyst 2. Two directing effects, i.e., an o-hydroxyphenyl coupled to a bulky aromatic on the opposite side of the… read more here.
Keywords: hydroxyphenyl ketones; directing effects; asymmetric transfer; transfer hydrogenation ... See more keywords