4-Hydroxyphenyl Retinamide Preferentially Targets FLT3 Mutated Acute Myeloid Leukemia via ROS Induction and NF-κB Inhibition
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DOI: 10.1007/s11596-020-2259-0
Abstract: FMS-like tyrosine kinase 3 (FLT3) mutation is strongly associated with poor prognosis in acute myeloid leukemia (AML). Though many FLT3 inhibitors have been developed for clinical application with 34%–56% complete remission rate, patients would develop… read more here.
Keywords: hydroxyphenyl retinamide; myeloid leukemia; flt3 mutated; aml cells ... See more keywords