In an in‐vitro model using human fetal membranes, 17‐&agr; hydroxyprogesterone caproate is not an optimal progestogen for inhibition of fetal membrane weakening
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Obstetrics and Gynecology"
DOI: 10.1016/j.ajog.2017.10.004
Abstract: Background The progestogen 17‐&agr; hydroxyprogesterone caproate (17‐OHPC) is 1 of only 2 agents recommended for clinical use in the prevention of spontaneous preterm delivery, and studies of its efficacy have been conflicting. We have developed… read more here.
Keywords: fetal membrane; hydroxyprogesterone caproate; factor; membrane weakening ... See more keywords
SMFM Statement: Use of 17-alpha hydroxyprogesterone caproate for prevention of recurrent preterm birth.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of obstetrics and gynecology"
DOI: 10.1016/j.ajog.2020.04.001
Abstract: B16 JULY 20 In late 2019, results from the Progestin’s Role in Optimizing Neonatal Gestation (PROLONG) trial were published showing no benefit of weekly injections of 17-alpha hydroxyprogesterone caproate (17-)HPC) from 16-20 weeks of gestation… read more here.
Keywords: smfm statement; alpha hydroxyprogesterone; hydroxyprogesterone caproate; statement use ... See more keywords
Characterization of new crystalline forms of hydroxyprogesterone caproate.
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DOI: 10.1016/j.ijpharm.2017.05.031
Abstract: A systematic polymorph screening process was conducted on the steroid hydroxyprogesterone caproate, which had only one previously described orthorhombic crystalline form (A), in order to fully elucidate its solid state properties. Cooling, anti-solvent and evaporative… read more here.
Keywords: crystalline forms; form; new crystalline; hydroxyprogesterone caproate ... See more keywords
17-Hydroxyprogesterone caproate improves hypertension and renal endothelin-1 in response to sFlt-1 induced hypertension in pregnant rats.
Sign Up to like & getrecommendations! Published in 2020 at "Pregnancy hypertension"
DOI: 10.1016/j.preghy.2020.09.002
Abstract: Preeclampsia (PE) is characterized by new onset hypertension in association with elevated soluble fms-like tyrosine kinase-1 (sFlt-1) and preproendothelin-1 (PPET-1) levels. Currently there is no effective treatment for PE except for early delivery of the… read more here.
Keywords: sflt; response; pregnant rats; hydroxyprogesterone caproate ... See more keywords
Impact of Pregnancy History and 17‐Hydroxyprogesterone Caproate on Cervical Cytokines and Matrix Metalloproteinases
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DOI: 10.1055/s-0037-1608631
Abstract: Objective The objective of this study was to evaluate the impact of pregnancy history and 17‐hydroxyprogesterone caproate (17‐OHPC) treatment on cervical fluid cytokines and matrix metalloproteinases (MMPs). Study Design Cervical fluid was obtained between 160/7… read more here.
Keywords: cervical fluid; history; pregnancy history; hydroxyprogesterone caproate ... See more keywords
PROLONG Clinical Study Protocol: Hydroxyprogesterone Caproate to Reduce Recurrent Preterm Birth.
Sign Up to like & getrecommendations! Published in 2018 at "American journal of perinatology"
DOI: 10.1055/s-0038-1642062
Abstract: The objective of this commentary is to describe the background, rationale, and methods of the PROLONG (Progestin's Role in Optimizing Neonatal Gestation) trial, which is a multicenter, multinational, placebo-controlled, randomized clinical trial (RCT) designed to… read more here.
Keywords: preterm birth; hydroxyprogesterone caproate; trial; study ... See more keywords
Factors Associated with Utilization of 17-Hydroxyprogesterone Caproate for the Prevention of Recurrent Preterm Birth.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of perinatology"
DOI: 10.1055/s-0039-1678532
Abstract: OBJECTIVE Weekly 17-hydroxyprogesterone caproate (17OHP-C) from 16 to 36 weeks' gestation reduces the risk of recurrent spontaneous preterm birth (sPTB). Limited data suggest poor adherence to published guidelines. This study aimed to identify factors associated… read more here.
Keywords: recurrent; preterm birth; hydroxyprogesterone caproate; factors associated ... See more keywords
Utilization, adherence, and outcomes of 17-alpha hydroxyprogesterone caproate for recurrent spontaneous preterm birth prevention
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DOI: 10.1080/03007995.2021.1933928
Abstract: Abstract Objective To describe the use of and adherence to 17-alpha hydroxyprogesterone caproate (17-OHPC), explore factors associated with its utilization and adherence, and to investigate the outcomes of 17-OHPC in a real-world setting. Methods The… read more here.
Keywords: alpha hydroxyprogesterone; utilization adherence; preterm birth; hydroxyprogesterone caproate ... See more keywords
Effect of weekly 17-hydroxyprogesterone caproate on small for gestational age among pregnant women with HIV in Zambia.
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DOI: 10.1097/qad.0000000000003362
Abstract: The IPOP trial demonstrated a reduced risk of severe small for gestational age among infants born to women with HIV who received weekly intramuscular 17 alpha-hydroxyprogesterone caproate. This secondary analysis examined the 17P treatment effect… read more here.
Keywords: women hiv; hydroxyprogesterone caproate; gestational age; age among ... See more keywords
Regional differences in utilization of 17α-hydroxyprogesterone caproate (17-OHP)
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DOI: 10.1515/jpm-2021-0586
Abstract: Abstract Objectives To describe regional differences in utilization of 17α-hydroxyprogesterone caproate (17-OHP). Methods Retrospective cohort study of a large, US commercial managed care plan claims database with pharmacy coverage from 2008 to 2018. Singleton pregnancies… read more here.
Keywords: regional differences; caproate ohp; utilization; hydroxyprogesterone caproate ... See more keywords
17α-Hydroxyprogesterone Caproate Inhibits Cytokine Production via Suppression of NF-κB Activation
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DOI: 10.3389/fphar.2022.831315
Abstract: Cytokine release syndrome (CRS) is one of the leading causes of morbidity and mortality in COVID-19 patients with elevated levels of circulating cytokines contributing to various clinical symptoms. Favorable control of CRS represents a promising… read more here.
Keywords: production; suppression; cytokine production; hydroxyprogesterone caproate ... See more keywords