Structural basis for the stereospecific inhibition of the dual proline/hydroxyproline catabolic enzyme ALDH4A1 by trans‐4‐hydroxy‐L‐proline
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4131
Abstract: Aldehyde dehydrogenase 4A1 (ALDH4A1) catalyzes the final steps of both proline and hydroxyproline catabolism. It is a dual substrate enzyme that catalyzes the NAD+‐dependent oxidations of L‐glutamate‐γ‐semialdehyde to L‐glutamate (proline metabolism), and 4‐hydroxy‐L‐glutamate‐γ‐semialdehyde to 4‐erythro‐hydroxy‐L‐glutamate… read more here.
Keywords: inhibition; hydroxyproline; enzyme; proline ... See more keywords
Hydroxyproline and starch consumption and urinary supersaturation with calcium oxalate in cats
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DOI: 10.1016/j.anifeedsci.2018.10.001
Abstract: Abstract The effect of extruded foods intake with different contents of starch, protein and hydroxyproline were evaluated on water balance, oxalate renal excretion, urine chemical composition and the relative urine supersaturation with calcium oxalate (RSSCaOx)… read more here.
Keywords: hydroxyproline starch; supersaturation calcium; hydroxyproline; calcium oxalate ... See more keywords
The Stickland Reaction Precursor trans-4-Hydroxy-l-Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia
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DOI: 10.1128/msphere.00926-21
Abstract: Proline is an essential environmental amino acid that C. difficile uses to support growth and cause significant disease. A posttranslationally modified form, hydroxyproline, is highly abundant in collagen, which is degraded by host proteases in… read more here.
Keywords: commensal clostridia; metabolism; hydroxyproline; difficile ... See more keywords
Evidence for co-translational misincorporation of non-canonical amino acid hydroxyproline in recombinant antibodies produced in Chinese Hamster Ovary (CHO) cell lines
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DOI: 10.1371/journal.pone.0241250
Abstract: With the advent of highly sensitive technologies such as tandem mass spectrometry and next-generation sequencing, recombinant antibodies are now routinely analyzed for the presence of low-level sequence variants including amino acid misincorporations. During mAb cell… read more here.
Keywords: translational misincorporation; amino acid; hydroxyproline; non canonical ... See more keywords
The regulatory mechanisms of proline and hydroxyproline metabolism: Recent advances in perspective
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1118675
Abstract: For diverse human tumors, growth and metastasis are dependent on proline synthesis, but the mechanisms underlying this association are not clear. Proline incorporated into collagen is primarily synthesized from glutamine. Thus, rates of collagen synthesis… read more here.
Keywords: metabolism; proline hydroxyproline; collagen; hydroxyproline ... See more keywords
Catabolism of Hydroxyproline in Vertebrates: Physiology, Evolution, Genetic Diseases and New siRNA Approach for Treatment
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23021005
Abstract: Hydroxyproline is one of the most prevalent amino acids in animal proteins. It is not a genetically encoded amino acid, but, rather, it is produced by the post-translational modification of proline in collagen, and a… read more here.
Keywords: catabolism hydroxyproline; hydroxyproline vertebrates; hydroxyproline; physiology ... See more keywords