Recent advances, challenges and metabolic engineering strategies in the biosynthesis of 3‐hydroxypropionic acid
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28170
Abstract: As an attractive and valuable platform chemical, 3‐hydroxypropionic acid (3‐HP) can be used to produce a variety of industrially important commodity chemicals and biodegradable polymers. Moreover, the biosynthesis of 3‐HP has drawn much attention in… read more here.
Keywords: hydroxypropionic acid; metabolic engineering; engineering strategies; advances challenges ... See more keywords
Exploiting tandem repetitive promoters for high-level production of 3-hydroxypropionic acid
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-09772-5
Abstract: High-level biosynthesis of desired metabolites is challenging due to complexity of metabolic networks. Here, we report that platform chemical 3-hydroxypropionic acid (3-HP) can be overproduced through promoter engineering and growth-sustaining cultivation, two parallel strategies relying… read more here.
Keywords: high level; tandem repetitive; hydroxypropionic acid; promoter ... See more keywords
Nitrile-hydrolyzing enzyme from Meyerozyma guilliermondii and its potential in biosynthesis of 3-hydroxypropionic acid
Sign Up to like & getrecommendations! Published in 2017 at "Bioprocess and Biosystems Engineering"
DOI: 10.1007/s00449-017-1754-6
Abstract: Abstract3-Hydroxypropionic acid (3-HP) is an important platform chemical in organic synthesis. Traditionally, 3-HP was produced by chemical methods and fermentation process. In this work, a novel enzymatic method was developed for green synthesis of 3-HP.… read more here.
Keywords: guilliermondii; hydrolyzing enzyme; nitrile hydrolyzing; hydroxypropionic acid ... See more keywords
Development of Biosensor for 3-Hydroxypropionic Acid
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioprocess Engineering"
DOI: 10.1007/s12257-018-0380-8
Abstract: In this study, whole-cell biosensors that detect and indicate the concentration of 3-hydroxypropionic acid (3-HP) by producing a green fluorescent signal were developed using a transcription factor (TF)-responsive 3-HP inducible promoter identified in the Pseudomonas… read more here.
Keywords: biosensor hydroxypropionic; development biosensor; hydroxypropionic acid; acid ... See more keywords
New insights in reactive extraction mechanisms of organic acids: An experimental approach for 3-hydroxypropionic acid extraction with tri-n-octylamine
Sign Up to like & getrecommendations! Published in 2017 at "Separation and Purification Technology"
DOI: 10.1016/j.seppur.2017.02.018
Abstract: A detailed study of 3-hydroxypropionic acid (3-HP) reactive extraction with tri-n-octylamine (TOA) is proposed for the first time. It aims at uncovering some solvent-solutes interactions and providing global mechanisms to better understand and design the… read more here.
Keywords: tri octylamine; extraction; reactive extraction; extraction tri ... See more keywords
Recovery of 3-hydroxypropionic acid from organic phases after reactive extraction with amines in an alcohol-type solvent
Sign Up to like & getrecommendations! Published in 2019 at "Separation and Purification Technology"
DOI: 10.1016/j.seppur.2019.02.026
Abstract: Abstract Reactive extraction is a well-known method for the recovery of organic acids from dilute streams. The extraction through complex formation with amines is followed by its back-extraction. Their affinity for amine extractants makes their… read more here.
Keywords: extraction; hydroxypropionic acid; reactive extraction; recovery hydroxypropionic ... See more keywords
Engineering an aldehyde dehydrogenase toward its substrates, 3-hydroxypropanal and NAD+, for enhancing the production of 3-hydroxypropionic acid
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-15400-x
Abstract: Abstract3-Hydroxypropionic acid (3-HP) can be produced via the biological route involving two enzymatic reactions: dehydration of glycerol to 3-hydroxypropanal (3-HPA) and then oxidation to 3-HP. However, commercial production of 3-HP using recombinant microorganisms has been… read more here.
Keywords: dehydrogenase; kgsadh; production; hpa ... See more keywords
Structural insights into the production of 3-hydroxypropionic acid by aldehyde dehydrogenase from Azospirillum brasilense
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46005
Abstract: 3-Hydroxypropionic acid (3-HP) is an important platform chemical to be converted to acrylic acid and acrylamide. Aldehyde dehydrogenase (ALDH), an enzyme that catalyzes the reaction of 3-hydroxypropionaldehyde (3-HPA) to 3-HP, determines 3-HP production rate during… read more here.
Keywords: dehydrogenase azospirillum; dehydrogenase; acid; production ... See more keywords
Simultaneous determination of 3-hydroxypropionic acid, methylmalonic acid and methylcitric acid in dried blood spots: Second-tier LC-MS/MS assay for newborn screening of propionic acidemia, methylmalonic acidemias and combined remethylation disorders
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DOI: 10.1371/journal.pone.0184897
Abstract: Background and aims Increased propionylcarnitine levels in newborn screening are indicative for a group of potentially severe disorders including propionic acidemia (PA), methylmalonic acidemias and combined remethylation disorders (MMACBL). This alteration is relatively non-specific, resulting… read more here.
Keywords: methylmalonic acid; determination; hydroxypropionic acid; methylcitric acid ... See more keywords
Integration of Proteomics and Metabolomics Into the Design, Build, Test, Learn Cycle to Improve 3-Hydroxypropionic Acid Production in Aspergillus pseudoterreus
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2021.603832
Abstract: Biological engineering of microorganisms to produce value-added chemicals is a promising route to sustainable manufacturing. However, overproduction of metabolic intermediates at high titer, rate, and yield from inexpensive substrates is challenging in non-model systems where… read more here.
Keywords: integration proteomics; aspergillus pseudoterreus; production; hydroxypropionic acid ... See more keywords
Enhanced 3-Hydroxypropionic Acid Production From Acetate via the Malonyl-CoA Pathway in Corynebacterium glutamicum
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2021.808258
Abstract: Acetate is an economical and environmental-friendly alternative carbon source. Herein, the potential of harnessing Corynebacterium glutamicum as a host to produce 3-hydroxypropionic acid (3-HP) from acetate was explored. First, the expression level of malonyl-CoA reductase… read more here.
Keywords: hydroxypropionic acid; corynebacterium glutamicum; acetate; malonyl coa ... See more keywords