Long-Term Neuropsychological Outcomes from an Open-Label Phase I/IIa Trial of 2-Hydroxypropyl-β-Cyclodextrins (VTS-270) in Niemann-Pick Disease, Type C1
Sign Up to like & getrecommendations! Published in 2019 at "CNS Drugs"
DOI: 10.1007/s40263-019-00642-2
Abstract: BackgroundNiemann-Pick disease, type C1 (NPC1) is a neurodegenerative condition that arises from mutations of NPC1 and is often diagnosed in children. Recently, several drug trials have been implemented to minimize neurodegeneration, including a trial of… read more here.
Keywords: hydroxypropyl; disease; vts 270; type ... See more keywords
A facile method to control the phase behavior of hydroxypropyl cellulose.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2020.117015
Abstract: We report a facile chemical method to convert the hydroxyl groups of hydroxypropyl cellulose (HPC) into carbamates. It was achieved by the reaction of HPC with N-methyl carbamoylimidazole, which is a safe and easy to… read more here.
Keywords: control phase; method control; hydroxypropyl; facile method ... See more keywords
An improved method to determine the hydroxypropyl content in modified starches by 1H NMR.
Sign Up to like & getrecommendations! Published in 2019 at "Food chemistry"
DOI: 10.1016/j.foodchem.2019.05.152
Abstract: Hydroxypropyl (HP) starches are used as thickeners and stabilizers in foods. The properties of the etherified starches are dependent on the degree of hydroxypropylation. The objective of this study was to develop an improved acid… read more here.
Keywords: content modified; modified starches; content; method ... See more keywords
Effect of processing conditions on microstructures and properties of hydroxypropyl methylcellulose/hydroxypropyl starch blends
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DOI: 10.1016/j.foodhyd.2017.03.019
Abstract: Abstract Since hydroxypropyl methylcellulose (HPMC) is a thermal gel while hydroxypropyl starch (HPS) is a cool gel, their blends show some unique and interesting behaviors of phase transitions and microstructures, which control their performances. This… read more here.
Keywords: effect processing; hydroxypropyl methylcellulose; hydroxypropyl starch; hydroxypropyl ... See more keywords
Inclusion complex of antiasthmatic compound with 2-hydroxypropyl-β-cyclodextrin: Preparation and physicochemical properties
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2017.04.098
Abstract: Abstract This work aims at obtaining 2-hydroxypropyl-β-cyclodextrin inclusion complex with an original antiasthmatic compound in buffer solution and solid state with higher solubility and, hence, bioavailability. The compound solubility with different 2-hydroxypropyl-β-cyclodextrin concentrations has been… read more here.
Keywords: hydroxypropyl; hydroxypropyl cyclodextrin; compound; solubility ... See more keywords
Characterization of hydroxypropyl-beta-cyclodextrins used in the treatment of Niemann-Pick Disease type C1
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DOI: 10.1371/journal.pone.0175478
Abstract: 2-Hydroxypropyl-beta-cyclodextrin (HPβCD) has gained recent attention as a potential therapeutic intervention in the treatment of the rare autosomal-recessive, neurodegenerative lysosomal storage disorder Niemann-Pick Disease Type C1 (NPC1). Notably, HPβCD formulations are not comprised of a… read more here.
Keywords: hydroxypropyl; vts 270; hydroxypropyl beta; pick disease ... See more keywords
Hydroxypropyl Methylcellulose Phthalate Biopolymer as an Anticorrosion Coating
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DOI: 10.20964/2021.09.44
Abstract: This study involved a carbohydrate material: hydroxypropyl methyl-cellulose phthalate (HPMCP), a derivative of the biopolymer hydroxypropyl methylcellulose. It is a biodegradable and environmentally friendly material. This study tested the durability and corrosion resistance of HPMCP… read more here.
Keywords: hydroxypropyl methylcellulose; phthalate; hydroxypropyl; biopolymer ... See more keywords
In Vitro and In Vivo Evaluation of Hydroxypropyl-β-cyclodextrin-grafted-poly(acrylic acid)/poly(vinyl pyrrolidone) Semi-Interpenetrating Matrices of Dexamethasone Sodium Phosphate
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15111399
Abstract: In this paper, we fabricated semi-interpenetrating polymeric network (semi-IPN) of hydroxypropyl-β-cyclodextrin-grafted-poly(acrylic acid)/poly(vinyl pyrrolidone) (HP-β-CD-g-poly(AA)/PVP) by the free radical polymerization technique, intended for colon specific release of dexamethasone sodium phosphate (DSP). Different proportions of polyvinyl pyrrolidone… read more here.
Keywords: hydroxypropyl; poly; semi; acrylic acid ... See more keywords
Cavity Closure of 2-Hydroxypropyl-β-Cyclodextrin: Replica Exchange Molecular Dynamics Simulations
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DOI: 10.3390/polym11010145
Abstract: 2-Hydroxypropyl-β-cyclodextrin (HPβCD) has unique properties to enhance the stability and the solubility of low water-soluble compounds by inclusion complexation. An understanding of the structural properties of HPβCD and its derivatives, based on the number of… read more here.
Keywords: molecular dynamics; hydroxypropyl; replica exchange; cavity ... See more keywords
Environmental-Friendly Adsorbent Composite Based on Hydroxyapatite/Hydroxypropyl Methyl-Cellulose for Removal of Cationic Dyes from an Aqueous Solution
Sign Up to like & getrecommendations! Published in 2022 at "Polymers"
DOI: 10.3390/polym14112147
Abstract: The aim of this study is to develop a new, efficient, and inexpensive natural-based adsorbent with high efficacy for the cationic dye methylene blue (MB). A natural-based nanocomposite based on hydroxyapatite (HAp) and hydroxypropyl methylcellulose… read more here.
Keywords: adsorption; based hydroxyapatite; hydroxypropyl; dyes aqueous ... See more keywords