Effect of Curcumin-Hydroxypropyl-$$\beta$$-Cyclodextrin Complex and the Complex Loaded Gelatin Carrageenan Microparticles on the Various Chemical and Biological Properties
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pharmaceutical Innovation"
DOI: 10.1007/s12247-021-09559-0
Abstract: Curcumin was modified with 2-hydroxypropyl- $$\beta$$ -cyclodextrin (HP $$\beta$$ CD) to enhance its bioavailability. The modified curcumin was loaded into gelatin-carrageenan microparticles to control the drug release behavior. The different analytical techniques like Fourier transform… read more here.
Keywords: microscopy; curcumin; spectroscopy; beta cyclodextrin ... See more keywords
Liquiritin-hydroxypropyl-beta-cyclodextrin inclusion complex: preparation, characterization, bioavailability and antitumor activity evaluation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2022.03.021
Abstract: The pharmacological activities of liquiritin (LT) are greatly limited by its insolubility and low oral absorption. The purpose of this study was to prepare LT-hydroxypropyl-beta-cyclodextrin inclusion complex (LT-HP-β-CD) to increase water solubility, oral bioavailability and… read more here.
Keywords: bioavailability; cyclodextrin inclusion; activity; beta cyclodextrin ... See more keywords
Inclusion Complexation of Etodolac with Hydroxypropyl-beta-cyclodextrin and Auxiliary Agents: Formulation Characterization and Molecular Modeling Studies.
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DOI: 10.1021/acs.molpharmaceut.6b01115
Abstract: The present investigation was aimed to prepare inclusion complexes of a therapeutically important nonsteroidal anti-inflammatory drug, etodolac (ETD) with hydroxypropyl-beta-cyclodextrin (HP-β-CD) and to study the effect of l-arginine (l-Arg) as an auxiliary agent on the… read more here.
Keywords: inclusion; complexation; etodolac; hydroxypropyl beta ... See more keywords
Study of the complexation of structurally modified curcumin with hydroxypropyl beta cyclodextrin and its effect on anticancer activity
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DOI: 10.1039/c9nj04408f
Abstract: There is evidence that the structural modification of curcumin (CUR) into its pyrazole form (CP) and the complexation of CUR with hydroxypropyl beta cyclodextrin (HPβCD) both improve curcumin's chemical–physical properties and enhance its biological activities.… read more here.
Keywords: microscopy; complexation; hydroxypropyl beta; spectroscopy ... See more keywords
Direct administration of 2-Hydroxypropyl-Beta-Cyclodextrin into guinea pig cochleae: Effects on physiological and histological measurements
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0175236
Abstract: 2-Hydroxypropyl-Beta-Cyclodextrin (HPβCD) can be used to treat Niemann-Pick type C disease, Alzheimer’s disease, and atherosclerosis. But, a consequence is that HPβCD can cause hearing loss. HPβCD was recently found to be toxic to outer hair… read more here.
Keywords: guinea pig; cyclodextrin; hydroxypropyl beta; pig cochleae ... See more keywords
Characterization of hydroxypropyl-beta-cyclodextrins used in the treatment of Niemann-Pick Disease type C1
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DOI: 10.1371/journal.pone.0175478
Abstract: 2-Hydroxypropyl-beta-cyclodextrin (HPβCD) has gained recent attention as a potential therapeutic intervention in the treatment of the rare autosomal-recessive, neurodegenerative lysosomal storage disorder Niemann-Pick Disease Type C1 (NPC1). Notably, HPβCD formulations are not comprised of a… read more here.
Keywords: hydroxypropyl; vts 270; hydroxypropyl beta; pick disease ... See more keywords
2-Hydroxypropyl-beta-cyclodextrin Treatment Does Not Induce Atherosclerotic Lesion Regression in Western-Type Diet-Fed Apolipoprotein E Knockout Mice
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DOI: 10.3390/biom12091205
Abstract: 2-Hydroxypropyl-beta-cyclodextrin (2HPβCD) is able to bind and solubilize unesterified cholesterol and may therefore be able to reverse the deposition of cholesterol in macrophages within the aortic vessel wall, a hallmark of atherosclerotic cardiovascular disease. However,… read more here.
Keywords: regression; apolipoprotein knockout; beta cyclodextrin; lesion ... See more keywords
Hydroxypropyl-Beta Cyclodextrin Barrier Prevents Respiratory Viral Infections: A Preclinical Study
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DOI: 10.3390/ijms25042061
Abstract: The emergence and mutation of pathogenic viruses have been occurring at an unprecedented rate in recent decades. The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has developed into… read more here.
Keywords: sars cov; hydroxypropyl beta; barrier; cyclodextrin ... See more keywords
Polysorbates versus Hydroxypropyl Beta-Cyclodextrin (HPβCD): Comparative Study on Excipient Stability and Stabilization Benefits on Monoclonal Antibodies
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DOI: 10.3390/molecules27196497
Abstract: Polysorbates (PS 20 and PS 80) are the most widely used surfactants in biopharmaceutical formulations to protect proteins from denaturation, aggregation, and surface adsorption. To date, around 70% of marketed therapeutic antibodies contain either PS… read more here.
Keywords: aggregation; beta cyclodextrin; stability; degradation ... See more keywords
Effects of Hydroxypropyl-Beta-Cyclodextrin on Cultured Brain Endothelial Cells
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DOI: 10.3390/molecules27227738
Abstract: The application of 2-hydroxypropyl-beta-cyclodextrin (HPBCD) in the treatment of the rare cholesterol and lipid storage disorder Niemann–Pick disease type C opened new perspectives in the development of an efficient therapy. Even if the systemic administration… read more here.
Keywords: endothelial cells; hpbcd; brain; beta cyclodextrin ... See more keywords
Investigation on the Combined Effect of Hydroxypropyl Beta-Cyclodextrin (HPβCD) and Polysorbate in Monoclonal Antibody Formulation
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DOI: 10.3390/ph17040528
Abstract: Monoclonal antibodies require careful formulation due to their inherent stability limitations. Polysorbates are commonly used to stabilize mAbs, but they are prone to degradation, which results in unwanted impurities. KLEPTOSE® HPβCD (hydroxypropyl beta-cyclodextrin) has functioned… read more here.
Keywords: formulation; beta cyclodextrin; investigation combined; hydroxypropyl beta ... See more keywords