The Safety, Tolerability, and Pharmacokinetics of Active Ingredients From Hydroxysafflor Yellow A in Healthy Chinese Volunteers
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1487
Abstract: Hydroxysafflor yellow A (HSYA), an active ingredient extracted from Carthami flos, shows potential for treating ischemic stroke. This phase 1 study assessed the safety, tolerability, and pharmacokinetic (PK) properties of HSYA in healthy Chinese volunteers… read more here.
Keywords: healthy chinese; hydroxysafflor yellow; study; safety tolerability ... See more keywords
Hydroxysafflor yellow A attenuates allergic response of ovalbumin induced allergic rhinitis via Nrf2/HO-1 and inflammatory signaling pathways.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23783
Abstract: Allergic reaction is the most common nasal conditions worldwide and it will remain throughout life. The symptoms of an allergic reaction include sneezing, itching, hives, swelling, difficulty breathing, and a runny nose. Hydroxysafflor yellow A… read more here.
Keywords: ovalbumin induced; hydroxysafflor yellow; hya; induced allergic ... See more keywords
Topical application of Hydroxysafflor Yellow A accelerates the wound healing in streptozotocin induced T1DM rats
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.01.018
Abstract: Abstract To investigate the effects of Hydroxysafflor Yellow A (HSYA), which is derived from safflower, on the proliferation, migration and angiogenesis of cells in vitro and its potential efficacy in vivo when topically applied to… read more here.
Keywords: topical application; wound healing; hsya; hydroxysafflor yellow ... See more keywords
Protective effect of hydroxysafflor yellow A alone or in combination with acetylglutamine on cerebral ischemia reperfusion injury in rat: A PET study using 18F‐fuorodeoxyglucose
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.02.011
Abstract: Abstract Hydroxysafflor yellow A (HSYA) and acetylglutamine (NAG) are extensively applied in the treatment of brain injury. In this study, we investigated the neuroprotective effect and underlying mechanism of HSYA alone or together with NAG… read more here.
Keywords: hsya; cerebral ischemia; effect; hydroxysafflor yellow ... See more keywords
Oral Bioavailability-Enhancing and Anti-obesity Effects of Hydroxysafflor Yellow A in Natural Deep Eutectic Solvent
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DOI: 10.1021/acsomega.2c00457
Abstract: Hydroxysafflor yellow A (HSYA), a primary active component in Carthami Flos, has been extensively applied in the treatment of cardiometabolic diseases. In this study, a natural deep eutectic solvent composed of glucose and choline chloride… read more here.
Keywords: hsya; deep eutectic; hydroxysafflor yellow; obesity ... See more keywords
Elucidation of the biosynthetic pathway of hydroxysafflor yellow A
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DOI: 10.1038/s41467-025-59774-3
Abstract: Hydroxysafflor yellow A (HSYA) is a clinical investigational new drug for the treatment of acute ischemic stroke. It has a unique quinochalcone di-C-glycoside structure and is exclusively found in the flowers of safflower (Carthamus tinctorius).… read more here.
Keywords: biosynthetic pathway; hydroxysafflor yellow; biosynthesis hsya; hsya ... See more keywords
Hydroxysafflor yellow A exerts neuroprotective effect by reducing Aβ toxicity through inhibiting endoplasmic reticulum stress in oxygen-glucose deprivation/reperfusion cell model.
Sign Up to like & getrecommendations! Published in 2023 at "Rejuvenation research"
DOI: 10.1089/rej.2022.0054
Abstract: Ischemia stroke is thought to be one of vascular risks associated with neurodegenerative diseases, such as Alzheimer's disease (AD). Hydroxysafflor yellow A (HSYA) has been reported to protect against stroke and AD, while the underlying… read more here.
Keywords: endoplasmic reticulum; cell model; glucose deprivation; hydroxysafflor yellow ... See more keywords
Protective Effect of Hydroxysafflor Yellow A on Nephropathy by Attenuating Oxidative Stress and Inhibiting Apoptosis in Induced Type 2 Diabetes in Rat
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/7805393
Abstract: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus, and its prevalence has been increasing all over the world, which is also the leading cause of end-stage renal failure. Hydroxysafflor yellow A (HSYA) is… read more here.
Keywords: apoptosis; hydroxysafflor yellow; hsya; oxidative stress ... See more keywords
Hydroxysafflor Yellow A Suppresses Platelet Activating Factor-Induced Activation of Human Small Airway Epithelial Cells
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00859
Abstract: Hydroxysafflor yellow A (HSYA) is a chemical component isolated from the Chinese medicine Carthamus tinctorius L. HSYA has numerous pharmacological effects, including protecting against and mitigating some respiratory diseases such as acute lung injury and… read more here.
Keywords: platelet activating; human small; activating factor; hydroxysafflor yellow ... See more keywords
Hydroxysafflor Yellow A: A Systematical Review on Botanical Resources, Physicochemical Properties, Drug Delivery System, Pharmacokinetics, and Pharmacological Effects
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.579332
Abstract: Hydroxysafflower yellow A (HSYA), as a principal natural ingredient extracted from safflower (Carthamus tinctorius L.), has significant pharmacological activities, such as antioxidant, anti-inflammatory, anticoagulant, and anticancer effects. However, chemical instability and low bioavailability have been… read more here.
Keywords: systematical review; hydroxysafflor yellow; pharmacological effects; yellow systematical ... See more keywords
Integrating Network Pharmacology and Transcriptomic Strategies to Explore the Pharmacological Mechanism of Hydroxysafflor Yellow A in Delaying Liver Aging
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214281
Abstract: Aging affects the structure and function of the liver. Hydroxysafflor yellow A (HSYA) effectively improves liver aging (LA) in mice, but the potential mechanisms require further exploration. In this study, an integrated approach combining network… read more here.
Keywords: network; liver; signaling pathway; pharmacology ... See more keywords