Development of potential preclinical candidates with promising in vitro ADME profile for the inhibition of type 1 and type 2 17β-Hydroxysteroid dehydrogenases: Design, synthesis, and biological evaluation.
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DOI: 10.1016/j.ejmech.2019.05.084
Abstract: Estrogens are the major female sex steroid hormones, estradiol (E2) being the most potent form in humans. Disturbing the balance between E2 and its weakly active oxidized form estrone (E1) leads to diverse types of… read more here.
Keywords: hydroxysteroid; vitro adme; vitro; type ... See more keywords