An Oxidative Bioconjugation Strategy Targeted to a Genetically Encoded 5‐Hydroxytryptophan
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800111
Abstract: Approaches that enable the chemoselective, covalent modification of proteins in a site‐specific manner have emerged as a powerful technology for a wide range of applications. The electron‐rich unnatural amino acid 5‐hydroxytryptophan was recently genetically encoded… read more here.
Keywords: bioconjugation strategy; oxidative bioconjugation; genetically encoded; strategy targeted ... See more keywords
Selective incorporation of 5‐hydroxytryptophan blocks long range electron transfer in oxalate decarboxylase
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DOI: 10.1002/pro.4537
Abstract: Oxalate decarboxylase from Bacillus subtilis is a binuclear Mn‐dependent acid stress response enzyme that converts the mono‐anion of oxalic acid into formate and carbon dioxide in a redox neutral unimolecular disproportionation reaction. A π‐stacked tryptophan… read more here.
Keywords: hydroxytryptophan; long range; range electron; electron transfer ... See more keywords
Effect of 5-hydroxytryptophan on fatigue in quiescent inflammatory bowel disease: a randomized controlled trial.
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DOI: 10.1053/j.gastro.2022.07.052
Abstract: BACKGROUND AND AIMS Fatigue is highly prevalent among patients suffering from inflammatory bowel disease (IBD) and only limited treatment options are available. Based on the hypothetical link between low serum tryptophan concentrations and fatigue, we… read more here.
Keywords: hydroxytryptophan; effect; inflammatory bowel; trial ... See more keywords
Oral Administration of 5-Hydroxytryptophan Restores Gut Microbiota Dysbiosis in a Mouse Model of Depression
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DOI: 10.3389/fmicb.2022.864571
Abstract: 5-Hydroxytryptophan (5-HTP) has positive clinical effects on various neuropsychiatric and metabiotic disorders, especially depression. Although it increases serotonin levels in the brain and gastrointestinal tract, its pharmacology remains largely unknown. Our goal was to determine… read more here.
Keywords: hydroxytryptophan; gut microbiota; pharmacology; depression ... See more keywords