Hydroxyurea Pharmacokinetics in Pediatric Patients After Total Pancreatectomy With Islet Autotransplantation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.1759
Abstract: Total pancreatectomy with islet autotransplantation is a complex surgical approach for acute recurrent or chronic pancreatitis that frequently triggers extreme thrombocytosis (platelets ≥ 1000 × 109 /L). Thrombocytosis can be prothrombotic, so cytoreductive hydroxyurea is… read more here.
Keywords: hydroxyurea; total pancreatectomy; pancreatectomy islet; islet autotransplantation ... See more keywords
Squamous cell carcinoma during long term hydroxyurea treatment: A case report
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Surgery Case Reports"
DOI: 10.1016/j.ijscr.2021.106160
Abstract: Background Hydroxyurea (HU) is a ribonucleotide diphosphate reductase inhibitor that interferes with the S phase of cell replication and inhibits DNA synthesis, with limited or no effect on RNA or protein synthesis. The cutaneous side… read more here.
Keywords: squamous cell; hydroxyurea treatment; hydroxyurea; case ... See more keywords
Quantification of hydroxyurea in human plasma by HPLC–MS/MS and its application to pharmacokinetics in patients with chronic myeloid leukaemia
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.01.008
Abstract: &NA; Hydroxyurea (HU) has been used in the treatment of chronic myeloid leukaemia (CML) and other myeloproliferative malignancies. Considering patient's wide variation in clinical response to HU, a new and simple liquid chromatography‐tandem mass spectrometry… read more here.
Keywords: plasma; method; myeloid leukaemia; hydroxyurea ... See more keywords
Hydroxyurea embryotoxicity is enhanced in P53-deficient mice.
Sign Up to like & getrecommendations! Published in 2018 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2018.06.011
Abstract: Hydroxyurea, a ribonucleotide reductase inhibitor, is a potent teratogen in mice, causing severe limb and skeletal defects. The exposure of gestation day nine murine embryos to hydroxyurea elicits an early embryonic stress response that involves… read more here.
Keywords: hydroxyurea embryotoxicity; hydroxyurea; mice; p53 ... See more keywords
A randomised double-blind placebo-controlled clinical trial of oral hydroxyurea for transfusion-dependent β-thalassaemia
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-06774-8
Abstract: Hydroxyurea is an antimetabolite drug that induces fetal haemoglobin in sickle cell disease. However, its clinical usefulness in β-thalassaemia is unproven. We conducted a randomised, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety… read more here.
Keywords: transfusion dependent; dependent thalassaemia; transfusion; oral hydroxyurea ... See more keywords
Hydroxyurea: a reappraisal of its cutaneous side effects and their management
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Dermatology"
DOI: 10.1111/ijd.15302
Abstract: Hydroxyurea (HU) is known to cause a broad spectrum of cutaneous side effects, ranging from relatively benign to severe. Although dermatologists are often consulted for the treatment of these side effects, a comprehensive resource discussing… read more here.
Keywords: cutaneous side; hydroxyurea; effects management; side ... See more keywords
Concomitant Hydroxyurea and Voxelotor: Results from the HOPE Study
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-130767
Abstract: Background: Sickle cell disease (SCD) is a chronic, debilitating disorder caused by a mutation in beta globin, which leads to the production of sickle hemoglobin (HbS). Deoxygenated HbS polymerization results in red blood cell (RBC)… read more here.
Keywords: board directors; advisory committees; membership entity; directors advisory ... See more keywords
Treatment of essential thrombocytopenia patients intolerant/ resistant to hydroxyurea: A physician survey.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e18565
Abstract: e18565Introduction: Hydroxyurea (HU) is deemed first-line cytoreductive therapy for patients with essential thrombocythemia (ET) at high-risk for vascular complications with 20-25% of patients deve... read more here.
Keywords: intolerant resistant; essential thrombocytopenia; thrombocytopenia patients; hydroxyurea ... See more keywords
The role of hydroxyurea in decreasing the occurrence of vasso-occulusive crisis in pediatric patients with sickle cell disease at King Saud Medical City in Riyadh, Saudi Arabia.
Sign Up to like & getrecommendations! Published in 2020 at "Saudi medical journal"
DOI: 10.15537/smj.2020.1.24698
Abstract: OBJECTIVES To measure the incidence of vaso-occlusive crises (VOC) and the role of hydroxyurea (HU) in reducing VOC in sickle cell anemia patients being treated at a large tertiary care setting in Kingdom of Saudi… read more here.
Keywords: saudi arabia; hydroxyurea; saud medical; role hydroxyurea ... See more keywords
The association between hydroxyurea adherence and opioid utilization among Texas Medicaid enrollees with sickle cell disease.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of managed care & specialty pharmacy"
DOI: 10.18553/jmcp.2020.26.11.1412
Abstract: BACKGROUND: Individuals with sickle cell disease (SCD) suffer from recurrent catastrophic pain crises that are often managed by opioid analgesics. Being adherent to hydroxyurea has been associated with decreased health care resource use for pain;… read more here.
Keywords: adherent hydroxyurea; opioid use; hydroxyurea; opioid prescriptions ... See more keywords
Preparation and Evaluation of a Liposome Drug Delivery System in Cancer Treatment in vitro
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Nanostructures"
DOI: 10.22052/jns.2020.01.015
Abstract: Cancer is a fatal disease and relatively widespread in the world; Breast cancer is the most prevalent cancer among women. Hydroxyurea (HU) is a chemotherapy drug for the cure of cancer different types in patients,… read more here.
Keywords: hydroxyurea; drug; cancer; breast cancer ... See more keywords