Hydroxyurea is associated with later onset of acute splenic sequestration crisis in sickle cell disease: Lessons from the European Sickle Cell Disease Cohort—Hydroxyurea (ESCORT‐HU) study
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DOI: 10.1002/ajh.27214
Abstract: Acute splenic sequestration crisis (ASSC) is a potentially life‐threatening complication of sickle cell disease (SCD), typically occurring in young patients under 5 years of age, with a median age at first episode of less than 2 years.… read more here.
Keywords: hydroxyurea; cell disease; sickle cell;
Hydroxyurea Pharmacokinetics in Pediatric Patients After Total Pancreatectomy With Islet Autotransplantation.
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DOI: 10.1002/jcph.1759
Abstract: Total pancreatectomy with islet autotransplantation is a complex surgical approach for acute recurrent or chronic pancreatitis that frequently triggers extreme thrombocytosis (platelets ≥ 1000 × 109 /L). Thrombocytosis can be prothrombotic, so cytoreductive hydroxyurea is… read more here.
Keywords: hydroxyurea; total pancreatectomy; pancreatectomy islet; islet autotransplantation ... See more keywords
Squamous cell carcinoma during long term hydroxyurea treatment: A case report
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DOI: 10.1016/j.ijscr.2021.106160
Abstract: Background Hydroxyurea (HU) is a ribonucleotide diphosphate reductase inhibitor that interferes with the S phase of cell replication and inhibits DNA synthesis, with limited or no effect on RNA or protein synthesis. The cutaneous side… read more here.
Keywords: squamous cell; hydroxyurea treatment; hydroxyurea; case ... See more keywords
Quantification of hydroxyurea in human plasma by HPLC–MS/MS and its application to pharmacokinetics in patients with chronic myeloid leukaemia
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.01.008
Abstract: &NA; Hydroxyurea (HU) has been used in the treatment of chronic myeloid leukaemia (CML) and other myeloproliferative malignancies. Considering patient's wide variation in clinical response to HU, a new and simple liquid chromatography‐tandem mass spectrometry… read more here.
Keywords: plasma; method; myeloid leukaemia; hydroxyurea ... See more keywords
Hydroxyurea embryotoxicity is enhanced in P53-deficient mice.
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DOI: 10.1016/j.reprotox.2018.06.011
Abstract: Hydroxyurea, a ribonucleotide reductase inhibitor, is a potent teratogen in mice, causing severe limb and skeletal defects. The exposure of gestation day nine murine embryos to hydroxyurea elicits an early embryonic stress response that involves… read more here.
Keywords: hydroxyurea embryotoxicity; hydroxyurea; mice; p53 ... See more keywords
mARC1 Is the Main Contributor to Metabolic Reduction of N-Hydroxyurea
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DOI: 10.1021/acs.jmedchem.4c01148
Abstract: N-Hydroxyurea has been known since the 1960s as an antiproliferative drug and is used both in oncology and for treatment of hematological disorders such as sickle cell anemia where very high daily doses are administered.… read more here.
Keywords: hydroxyurea; contributor metabolic; reduction; main contributor ... See more keywords
A randomised double-blind placebo-controlled clinical trial of oral hydroxyurea for transfusion-dependent β-thalassaemia
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DOI: 10.1038/s41598-022-06774-8
Abstract: Hydroxyurea is an antimetabolite drug that induces fetal haemoglobin in sickle cell disease. However, its clinical usefulness in β-thalassaemia is unproven. We conducted a randomised, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety… read more here.
Keywords: transfusion dependent; dependent thalassaemia; transfusion; oral hydroxyurea ... See more keywords
Hydroxyurea: a reappraisal of its cutaneous side effects and their management
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DOI: 10.1111/ijd.15302
Abstract: Hydroxyurea (HU) is known to cause a broad spectrum of cutaneous side effects, ranging from relatively benign to severe. Although dermatologists are often consulted for the treatment of these side effects, a comprehensive resource discussing… read more here.
Keywords: cutaneous side; hydroxyurea; effects management; side ... See more keywords
Concomitant Hydroxyurea and Voxelotor: Results from the HOPE Study
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DOI: 10.1182/blood-2019-130767
Abstract: Background: Sickle cell disease (SCD) is a chronic, debilitating disorder caused by a mutation in beta globin, which leads to the production of sickle hemoglobin (HbS). Deoxygenated HbS polymerization results in red blood cell (RBC)… read more here.
Keywords: board directors; advisory committees; membership entity; directors advisory ... See more keywords
Stroke Training, Research, and Education Toward Capacity with Hydroxyurea (STRETCH)
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DOI: 10.1182/blood-2024-208160
Abstract: Introduction: Sickle cell anemia (SCA) is an inherited hematological disease characterized by recurrent painful events, susceptibility to infections, and progressive organ failure. SCA is associated with increased morbidity and mortality, particularly in children under age… read more here.
Keywords: education; tcd; capacity; hydroxyurea ... See more keywords
Effects of Splenomegaly in Children with Sickle Cell Anemia Treated with Hydroxyurea: Secondary Analysis of the Sphere Trial
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DOI: 10.1182/blood-2024-208408
Abstract: Introduction: Sickle cell anemia (SCA) typically causes splenic dysfunction and atrophy early in life, but in sub-Saharan Africa, many children have persistent splenomegaly that can lead to splenic sequestration and hypersplenism with recurrent cytopenias. We… read more here.
Keywords: irr; splenomegaly; hydroxyurea; intermittent ... See more keywords