Hydroxyurea embryotoxicity is enhanced in P53-deficient mice.
Sign Up to like & getrecommendations! Published in 2018 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2018.06.011
Abstract: Hydroxyurea, a ribonucleotide reductase inhibitor, is a potent teratogen in mice, causing severe limb and skeletal defects. The exposure of gestation day nine murine embryos to hydroxyurea elicits an early embryonic stress response that involves… read more here.
Keywords: hydroxyurea embryotoxicity; hydroxyurea; mice; p53 ... See more keywords