Optimising genetic transformation of Trypanosoma cruzi using hydroxyurea-induced cell-cycle synchronisation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Biochemical Parasitology"
DOI: 10.1016/j.molbiopara.2018.07.002
Abstract: Highlights • A straightforward method for optimising Trypanosoma cruzi transfection efficiency.• Facilitated by hydroxyurea-induced cell-cycle synchronization.• Applicable to both episomal and integrative-mediated transformation.• Reduces the time required to generate genetically modified cell lines.• Increases the… read more here.
Keywords: cell cycle; hydroxyurea induced; cell; trypanosoma cruzi ... See more keywords
Hydroxyurea‐induced onychomadesis in a dog with chronic myeloid leukemia: A case report
Sign Up to like & getrecommendations! Published in 2018 at "Topics in Companion Animal Medicine"
DOI: 10.1053/j.tcam.2018.06.003
Abstract: ABSTRACT A 12‐year‐old Rottweiler dog was presented with a history of prostration, weight loss and hyporexia for six months. Based on complete blood tests (hematological and biochemical analyses), bone marrow examination and imaging analysis, a… read more here.
Keywords: myeloid leukemia; chronic myeloid; hydroxyurea induced; dog ... See more keywords
Therapeutic Dose of Hydroxyurea-Induced Synaptic Abnormalities on the Mouse Spermatocyte
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.666339
Abstract: Hydroxyurea (HU) is a widely used pharmacological therapy for sickle cell disease (SCD). However, replication stress caused by HU has been shown to inhibit premeiotic S-phase DNA, leading to reproductive toxicity in germ cells. In… read more here.
Keywords: therapeutic dose; induced synaptic; dose hydroxyurea; hydroxyurea ... See more keywords