Latent‐Functionality‐Based Synthesis of the Furanoside Motif of Hygromycin A
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DOI: 10.1002/ejoc.202500768
Abstract: Hygromycin A, a once‐forgotten antibiotic first isolated in 1953, is recently rediscovered as a novel inhibitor of Lyme disease caused by Borrelia burgdorferi. Given the increasing resistance of gut microbes to antibiotic treatments, there is… read more here.
Keywords: hygromycin; motif; based synthesis; functionality based ... See more keywords
Development of a yeast heterologous expression cassette based on the promoter and terminator elements of the Eremothecium cymbalariae translational elongation factor 1α (EcTEF1) gene
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DOI: 10.1007/s13205-018-1224-0
Abstract: A new expression cassette (EC0) consisting of the fused 5′ and 3′ intergenic regions (IGRs) of the Eremothecium cymbalariae translational elongation factor 1α (EcTEF1) gene was evaluated through expression of the bacterial hygromycin B phosphotransferase… read more here.
Keywords: cassette; hygromycin; gene; expression cassette ... See more keywords
Structural basis for hygromycin B inhibition of yeast pseudouridine-deficient ribosomes
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DOI: 10.1126/sciadv.adu0151
Abstract: Eukaryotic ribosomes are enriched with pseudouridine, particularly at the functional centers targeted by antibiotics. Here, we investigated the roles of pseudouridine in aminoglycoside-mediated translation inhibition by comparing the structural and functional properties of the yeast… read more here.
Keywords: pseudouridine free; hygromycin; inhibition; structural basis ... See more keywords