In Situ Transformable Nanoplatforms with Supramolecular Cross‐Linking Triggered Complementary Function for Enhanced Cancer Photodynamic Therapy
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202209944
Abstract: In vivo cross‐linking of nanoparticles is widely used to increase accumulation of therapeutic agents at tumor site for enhanced therapy. However, the components in nanoplatforms usually only play for one role and are independent of… read more here.
Keywords: cancer; hyp; cross linking; photodynamic therapy ... See more keywords
Engineering hydroxyproline‐O‐glycosylated biopolymers to reconstruct the plant cell wall for improved biomass processability
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27266
Abstract: Reconstructing the chemical and structural characteristics of the plant cell wall represents a promising solution to overcoming lignocellulosic biomass recalcitrance to biochemical deconstruction. This study aims to leverage hydroxyproline (Hyp)‐O‐glycosylation, a process unique to plant… read more here.
Keywords: cell wall; plant cell; plant; hyp ... See more keywords
Tissue-specific mineralization defects in the periodontium of the Hyp mouse model of X-linked hypophosphatemia.
Sign Up to like & getrecommendations! Published in 2017 at "Bone"
DOI: 10.1016/j.bone.2017.07.026
Abstract: X-linked hypophosphatemia (XLH) is a dento-osseous disorder caused by inactivating mutations in the PHEX gene, leading to renal phosphate wasting and hypophosphatemia, and impaired mineralization of bones and teeth. In the oral cavity, recent reports… read more here.
Keywords: xlh; cementum; tissue; bone ... See more keywords
Anti‐proliferative and anti‐migratory effects of hyperforin in 2D and 3D artificial constructs of human dermal fibroblasts – A new option for hypertrophic scar treatment?
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2017.03.003
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Hyperforin (HYP), one of the main bioactive compounds in extracts of Hypericum perforatum, is a potential drug candidate for the treatment of skin diseases. Since extracts have proven… read more here.
Keywords: human dermal; anti proliferative; treatment; hyp ... See more keywords
Comparison of gelatin and low-molecular weight gelatin hydrolysate ingestion on hydroxyproline (Hyp), Pro-Hyp and Hyp-Gly concentrations in human blood.
Sign Up to like & getrecommendations! Published in 2021 at "Food chemistry"
DOI: 10.1016/j.foodchem.2021.130869
Abstract: This study showed that gelatin ingestion significantly increased prolyl-hydroxyproline (Pro-Hyp) levels in plasma of 9 subjects, with maximum concentrations of 15.5 ± 3.0 nmol/mL 2 h post-ingestion. Hydroxyprolyl-glycine (Hyp-Gly) concentrations were significantly increased and reached a maximal level of… read more here.
Keywords: pro hyp; hyp gly; ingestion; hyp ... See more keywords
Preparation and validation of cyclodextrin-based excipients for radioiodinated hypericin applied in a targeted cancer radiotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120393
Abstract: BACKGROUND Iodine-131 labeled hypericin (131I-Hyp) has been utilized as a necrosis-avid theragnostic tracer in a dual targeting pan-anticancer strategy called OncoCiDia. Widespread use of previously-tested solvent dimethyl sulfoxide (DMSO) is limited by safety concerns. To… read more here.
Keywords: microscopy; cyclodextrin; histopathology; 131i hyp ... See more keywords
Importance of Hypericin-Bcl2 interactions for biological effects at subcellular levels.
Sign Up to like & getrecommendations! Published in 2019 at "Photodiagnosis and photodynamic therapy"
DOI: 10.1016/j.pdpdt.2019.08.016
Abstract: Hypericin (Hyp) is a naturally occurring compound used as photosensitizer in photodynamic therapy and diagnosis. Recently, we have shown that Hyp presence alone, without illumination, resulted in substantial biological effects at several sub-cellular levels. Hyp… read more here.
Keywords: hyp; bh3; hypericin; bcl2 ... See more keywords
Oxidation of [Ge9{Si(SiMe3)3}3]- with LnI3 (Ln = Eu, Sm, Yb): Isomerism of Metalloid Germanium Clusters.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c01501
Abstract: The oxidation of K[Ge9(Hyp)3] (Hyp = Si(SiMe3)3) with lanthanide triiodides LnI3 (Ln = Eu, Sm, Yb) leads to the formation of novel clusters with a Ge18-core isolated as a co-crystallizate of Ge*18(Hyp)6 (1a) and Ge18(Hyp)5(Si(SiMe3)2)(SiMe3)… read more here.
Keywords: hyp; oxidation ge9; sime3; isomerism metalloid ... See more keywords
[PtZn2Ge18(Hyp)8] (Hyp = Si(SiMe3)3): A Neutral Polynuclear Chain Compound with Ge9(Hyp)3 Units.
Sign Up to like & getrecommendations! Published in 2018 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.8b01757
Abstract: The reaction of [ZnGe18(Hyp)6] (Hyp = Si(SiMe3)3) with Pt(PPh3)4 gives the neutral polynuclear complex of Ge9(Hyp)3 units [HypZn-Ge9(Hyp)3-Pt-Ge9(Hyp)3-ZnHyp], 1. Within 1, the central Pt atom is bound η3 to both Ge9(Hyp)3 units to which further… read more here.
Keywords: hyp hyp; hyp units; ge9 hyp; hyp ... See more keywords
Characterization of Angiotensin-Converting Enzyme Inhibitory Activity of X-Hyp-Gly-Type Tripeptides: Importance of Collagen-Specific Prolyl Hydroxylation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b03648
Abstract: Hydroxyproline (Hyp) is a collagen-specific amino acid formed by post-translational hydroxylation of Pro residues. Various Hyp-containing oligopeptides are transported into the blood at high concentrations after oral ingestion of collagen hydrolysate. Here we investigated the… read more here.
Keywords: type tripeptides; hyp; hyp gly; gly type ... See more keywords
Thermoresponsive Liposomes for Photo-Triggered Release of Hypericin Cyclodextrin Inclusion Complex for Efficient Antimicrobial Photodynamic Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c02741
Abstract: Antimicrobial strategies with high efficacy against bacterial infections are urgently needed. The development of effective therapies to control bacterial infections is still a challenge. Herein, near-infrared (NIR)-activated thermosensitive liposomes (TSL) were loaded with the NIR-dye… read more here.
Keywords: inclusion complex; hyp; hypericin; cyclodextrin inclusion ... See more keywords