Progranulin sustains STAT3 hyper‐activation and oncogenic function in colorectal cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12552
Abstract: Persistent activation of Signal Transducer and Activator of Transcription (STAT)3 occurs in a high percentage of tumors, including colorectal cancer (CRC), thereby contributing to malignant cell proliferation and survival. Although STAT3 is recognized as an… read more here.
Keywords: colorectal cancer; hyper activation; activation; cancer cells ... See more keywords
A rare subset of primary tumor cells with concomitant hyper-activation of extracellular matrix remodeling and dsRNA-IFN1 signaling metastasizes in breast cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-2717
Abstract: Metastatic breast cancer (BC) has a poor prognosis and is largely considered incurable. A better understanding of the molecular determinants of BC metastasis could facilitate development of improved prevention and treatment strategies. We used lentiviral… read more here.
Keywords: activation extracellular; concomitant hyper; extracellular matrix; hyper activation ... See more keywords
Cognition, Behavior, Sexuality, and Autonomic Responses of Women with Hypothalamic Amenorrhea
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DOI: 10.3390/brainsci12111448
Abstract: (1) Background: Functional Hypothalamic Amenorrhea (FHA) can be caused by the hyper activation of neuro-endocrine responses to stress. Among other endocrine factors and hypothalamic dysfunctions, the psychophysiological stress response can very frequently lead to an… read more here.
Keywords: hypothalamic amenorrhea; stress; hyper activation; behavior sexuality ... See more keywords