Circumventing pyroptosis via hyperactivation shapes superior immune responses of human type 2 dendritic cells compared to type 3 dendritic cells.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250123
Abstract: Exploiting inflammasome activation in dendritic cells (DCs) is a promising approach to fight cancer and to augment adjuvant-induced immune responses. As inflammasome formation is typically accompanied by pyroptosis, hyperactivation - defined as inflammasome activation in… read more here.
Keywords: immune responses; hyperactivation; type dendritic; circumventing pyroptosis ... See more keywords
Iberiotoxin and clofilium regulate hyperactivation, acrosome reaction, and ion homeostasis synergistically during human sperm capacitation
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23671
Abstract: Potassium channels play essential roles in the regulation of male fertility. However, potassium channels mediating K+ currents in human sperm (IKSper) remain controversial. Besides SLO3, the SLO1 potassium channel is a potential candidate for human… read more here.
Keywords: capacitation; hyperactivation; clofilium; acrosome reaction ... See more keywords
Stress granules safeguard against MAPK signaling hyperactivation by sequestering PKC/Pck2: new findings and perspectives.
Sign Up to like & getrecommendations! Published in 2021 at "Current genetics"
DOI: 10.1007/s00294-021-01192-1
Abstract: Stress granule (SG) assembly is a conserved cellular strategy that copes with stress-related damage and promotes cell survival. SGs form through a process of liquid-liquid phase separation. Cellular signaling also appears to employ SG assembly… read more here.
Keywords: granules safeguard; stress granules; hyperactivation; mapk signaling ... See more keywords
Hyperactivation of the amygdala correlates with impaired social play behavior of prepubertal male rats in a maternal immune activation model
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113503
Abstract: Maternal infection during pregnancy is an environmental risk factor for neurodevelopmental dysfunction, such as autism spectrum disorder (ASD). This study investigated the effect of maternal immune activation (MIA) on the behavior profile of prepubertal offspring… read more here.
Keywords: social play; maternal immune; hyperactivation; play behavior ... See more keywords
Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14577
Abstract: NF-E2-related factor-2 (Nrf2) regulates cellular responses to oxidative and electrophilic stress. Loss of Keap1 increases Nrf2 protein levels, and Keap1-null mice die of oesophageal hyperkeratosis because of Nrf2 hyperactivation. Here we show that deletion of… read more here.
Keywords: null mice; hyperactivation; keap1 null; nephrogenic diabetes ... See more keywords
Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer’s disease mice and correlates with memory deficits in human subjects
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31073-6
Abstract: Calpain hyperactivation is implicated in late-stages of neurodegenerative diseases including Alzheimer’s disease (AD). However, calpains are also critical for synaptic function and plasticity, and hence memory formation and learning. Since synaptic deficits appear early in… read more here.
Keywords: calpain; specific hyperactivation; alzheimer disease; hyperactivation ... See more keywords
156 Effect of human tubal fluid medium and hyperactivation inducers on stallion sperm capacitation and hyperactivation
Sign Up to like & getrecommendations! Published in 2019 at "Reproduction, Fertility and Development"
DOI: 10.1071/rdv31n1ab156
Abstract: Conventional IVF has not yet been implemented in the equine species. One of the main reasons has been the inability to develop a culture medium and incubation conditions supporting high levels of stallion sperm capacitation… read more here.
Keywords: stallion sperm; capacitation; medium; membrane ... See more keywords
A vicious cycle of β amyloid–dependent neuronal hyperactivation
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aay0198
Abstract: Dissecting hyperactivation in AD Progressive accumulation of amyloid β (Aβ) in the brain is a defining feature of Alzheimer's disease (AD). At late stages of AD, pathological Aβ accumulations cause neurodegeneration and cell death. However,… read more here.
Keywords: dependent neuronal; amyloid dependent; hyperactivation; vicious cycle ... See more keywords
Lrg1 Regulates β (1,3)-Glucan Masking in Candida albicans through the Cek1 MAP Kinase Pathway
Sign Up to like & getrecommendations! Published in 2019 at "mBio"
DOI: 10.1128/mbio.01767-19
Abstract: Candida albicans is an important source of systemic infections in humans. The ability to mask the immunogenic cell wall polymer β (1,3)-glucan from host immune surveillance contributes to fungal virulence. We previously reported that the… read more here.
Keywords: lrg1; map kinase; cek1; cell wall ... See more keywords
YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/circresaha.118.313707
Abstract: Rationale: The Hippo pathway governs cellular differentiation, morphogenesis, and homeostasis, but how it regulates these processes in lymphatic vessels is unknown. Objective: We aimed to reveal the role of the final effectors of the Hippo… read more here.
Keywords: yap taz; lymphangiogenesis; yap; hyperactivation ... See more keywords
Disruption of dNTPs Homeostasis by Ribonucleotide Reductase Hyperactivation Overcomes AML Differentiation Blockade.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021015108
Abstract: Differentiation blockade is a hallmark of AML. Strategy to overcome such blockade is a promising approach against the disease. Lack of understanding underlying mechanisms hampers development of such strategy. Dysregulated ribonucleotide reductase (RNR) is considered… read more here.
Keywords: differentiation; differentiation blockade; ribonucleotide reductase; blockade ... See more keywords