RAS-MPAK Pathway Signaling in Health and Disease
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-109378
Abstract: The p21ras (Ras) family of signal switch molecules is an essential component of proliferative responses to many extracellular stimuli including most hematopoietic growth factors and cytokines. Phosphorylation of tyrosine residues on activated cytokine/growth factor receptors… read more here.
Keywords: ras proteins; hyperactive ras; ras mutations; disease ... See more keywords
Mutations predictive of hyperactive Ras signaling correlate with inferior survival across high-risk pediatric acute leukemia.
Sign Up to like & getrecommendations! Published in 2020 at "Translational pediatrics"
DOI: 10.21037/tp.2019.12.03
Abstract: Background Cancer remains the number one cause of disease-related mortality in children, and despite advances in the molecular understanding of leukemia and targeted therapies, refractory leukemia remains a leading cause of death. It therefore is… read more here.
Keywords: inferior survival; leukemia; hyperactive ras; high risk ... See more keywords