Na/K Pump Mutations Associated with Primary Hyperaldosteronism Cause Loss of Function.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00051
Abstract: Primary hyperaldosteronism (Conn's syndrome), a common cause of secondary hypertension, is frequently produced by unilateral aldosterone-producing adenomas that carry mutations in ion-transporting genes, including ATP1A1, encoding the Na/K pump's α1 subunit. Whether Na/K pump mutant-mediated… read more here.
Keywords: hyperaldosteronism; pump; primary hyperaldosteronism; inward currents ... See more keywords
Urinary sodium/potassium ratio as a screening tool for hyperaldosteronism in men with hypertension
Sign Up to like & getrecommendations! Published in 2021 at "Hypertension Research"
DOI: 10.1038/s41440-021-00663-9
Abstract: Among individuals with hypertension, the prevalence of secondary hypertension has been reported to be ≈10%. More than half of individuals with secondary hypertension have associated hyperaldosteronism. However, given the current clinical environment, these patients often… read more here.
Keywords: sodium potassium; hyperaldosteronism; men hypertension; urinary sodium ... See more keywords
G20 Neonatal hypertension as a result of transient hyperaldosteronism: case series
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2018-rcpch.19
Abstract: Neonatal hypertension (NH) is an uncommon but important clinical problem in neonates. The most important non-renal association with NH is Bronchopulmonary Dysplasia (BPD). Exact mechanism of hypertension in BPD infants is not known. The purpose… read more here.
Keywords: hyperaldosteronism; treatment; case series; case ... See more keywords
Abstract P2024: Treatment of Primary Hyperaldosteronism Increases Plasma Epoxyeicosatrienoic Acids
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension"
DOI: 10.1161/hyp.74.suppl_1.p2024
Abstract: Epoxyeicosatrienoic acids (EETs) are lipid signaling molecules formed from arachidonic acid by the action of CYP450s. EETs cause vasodilation, exert anti-inflammatory effects, and enhance insulin secretion and sensitivity. 14,15-DHET has been reported to be increased… read more here.
Keywords: eet; hyperaldosteronism; treatment primary; primary hyperaldosteronism ... See more keywords
Saga of Familial Hyperaldosteronism: Yet a New Channel
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DOI: 10.1161/hypertensionaha.118.11150
Abstract: In 1953, Litynski1 reported in a Polish journal the first case of an adrenocortical adenoma associated with hypertension and hypokalemia that was cured by adrenalectomy. Three years later, Conn2 reported a similar case and described… read more here.
Keywords: new channel; hyperaldosteronism; yet new; hyperaldosteronism yet ... See more keywords
Systematic Review of Therapeutic Agents and Long-Term Outcomes of Familial Hyperaldosteronism Type 1.
Sign Up to like & getrecommendations! Published in 2023 at "Hypertension"
DOI: 10.1161/hypertensionaha.123.21054
Abstract: BACKGROUND Familial hyperaldosteronism type 1 (FH1), previously known as glucocorticoid-remediable aldosteronism, was the first identified monogenic cause of primary aldosteronism. Patients classically develop hypertension at a young age and are at risk of premature vascular… read more here.
Keywords: long term; hyperaldosteronism; term treatment; age ... See more keywords
Surgical findings and outcomes after unilateral adrenalectomy for primary hyperaldosteronism in cats: a multi-institutional retrospective study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Feline Medicine and Surgery"
DOI: 10.1177/1098612x221135124
Abstract: Case series summary Twenty-nine cats from different institutions with confirmed or highly suspected primary hyperaldosteronism treated by unilateral adrenalectomy were retrospectively included in this study. The most frequent clinical signs were lethargy (n = 20; 69%) and… read more here.
Keywords: hyperaldosteronism; unilateral adrenalectomy; primary hyperaldosteronism; adrenalectomy ... See more keywords
Markers of potassium homeostasis in salt losing tubulopathies- associations with hyperaldosteronism and hypomagnesemia
Sign Up to like & getrecommendations! Published in 2020 at "BMC Nephrology"
DOI: 10.1186/s12882-020-01905-7
Abstract: Background Renal loss of potassium (K + ) and magnesium (Mg 2+ ) in salt losing tubulopathies (SLT) leads to significantly reduced Quality of Life (QoL) and higher risks of cardiac arrhythmia. The normalization of… read more here.
Keywords: hyperaldosteronism; salt losing; potassium homeostasis; losing tubulopathies ... See more keywords
Case report: schwannoma arising from the unilateral adrenal area with bilateral hyperaldosteronism
Sign Up to like & getrecommendations! Published in 2017 at "BMC Endocrine Disorders"
DOI: 10.1186/s12902-017-0225-z
Abstract: BackgroundWe report a rare case of a juxta-adrenal schwannoma that could not be discriminated from an adrenal tumor before surgical resection and was complicated by bilateral hyperaldosteronism. To the best of our knowledge, this is… read more here.
Keywords: schwannoma arising; juxta adrenal; hyperaldosteronism; aldosterone ... See more keywords
Epinephrine to the Rescue: Identifying the Offending Side in Bilateral (B/L) Macronodular Adrenal Hyperplasia (BMAH) With Cushing Syndrome (CS) and Hyperaldosteronism
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvab048.263
Abstract: Abstract Management of ACTH-independent CS in the setting of B/L adrenal masses can be challenging. We present a patient with concomitant cortisol and aldosterone hypersecretion and B/L adrenal masses who was treated with unilateral adrenalectomy… read more here.
Keywords: epinephrine; cortisol; macronodular adrenal; hyperaldosteronism ... See more keywords
ASO Author Reflections: Predicting Postoperative Resolution of Hypertension in Primary Hyperaldosteronism
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Surgical Oncology"
DOI: 10.1245/s10434-021-09762-w
Abstract: While hypokalemia routinely normalizes after unilateral adrenalectomy for primary hyperaldosteronism (PA), only one-third of patients will achieve postoperative normotension, and our ability to preoperatively identify those who will become normotensive remains both a priority and… read more here.
Keywords: resolution; hyperaldosteronism; author reflections; primary hyperaldosteronism ... See more keywords